LOSS OF RESIDUAL RENAL FUNCTION WAS NOT ASSOCIATED WITH GLYCEMIC CONTROL IN PATIENTS ON PERITONEAL DIALYSIS

Background: Better glycemic control has been reported to slow the progression of nephropathy in predialysis diabetic patients. However, the relationship between glycemic control and residual renal function (RRF) in patients on peritoneal dialysis (PD) is uncertain. Methods: 89 incident diabetic patients on PD were recruited from 5 centers. We measured glomerular filtration rate (GFR) and hemoglobin A1c (HbA1c) within 2 months ( baseline) after the start of PD and at 6 and 12 months. GFR was calculated as the average of renal creatinine and urea clearances. We analyzed whether mean HbA1c was associated with change in GFR(Delta GFR) over 1 year. Results: During the first year of PD, Delta GFR was -1.7 +/- 3.4 mL/min/ 1.73 m(2) and was not affected by mean HbA1c. Acute hemodialysis before starting PD and mean arterial diastolic pressure were related to the decline of GFR in a multivariate analysis. Conclusion: Glycemic control was not associated with change in RRF in diabetic patients during the first year after starting PD. Perit Dial Int 2011; 31:154-159 www.PDIConnect.com epub ahead of print: 31 Jan 2011 doi:10.3747/pdi.2009.00208