Enhanced binding of dopamine D1 receptors in Caudate-Putamen subregions in high-yawning Sprague-Dawley rats

Previous reports have shown that the inbred High-Yawning (HY) and Low-Yawning (LY) rats differ in several behavioral characteristics related to mesolimbic and nigrostriatal dopamine (DA) function. To determine if differential expression of DA receptors or DA transporter may mediate the behavioral differences in these two sublines of the Sprague-Dawley rat, we performed a quantitative autoradiography study of the DA D-1-like, D-2-like, and DA-transporter binding in the basal ganglia and nucleus accumbens. The results show that levels of the D, binding in the caudate-putamen of the HY rat were higher than in the LY animals, whereas no significant differences in the DA D-2 receptors and DA transporter were noted in these sublines. These data suggest that the differences in DA receptors in D, binding in HY rats may in part have contributed to the behavioral differences related to DA functions such as grooming and penile erection. Our findings are consistent with previous reports showing a decrease in the behavioral responses after systemic administration of DA agonist in LY compared to HY rats. (c) 2005 Wiley-Liss, Inc.