Eye color and the risk of skin cancer

被引:3
|
作者
Li, Yueyao [1 ]
Li, Wen-Qing [1 ,2 ,3 ]
Li, Tricia [1 ,4 ]
Qureshi, Abrar A. [1 ,3 ]
Cho, Eunyoung [1 ,3 ,4 ]
机构
[1] Brown Univ, Warren Alpert Med Sch, Dept Dermatol, Providence, RI 02912 USA
[2] Peking Univ Canc Hosp & Inst, Dept Canc Epidemiol, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Beijing, Peoples R China
[3] Brown Sch Publ Hlth, Dept Epidemiol, Providence, RI 02903 USA
[4] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA
关键词
Melanoma skin cancer; Nonmelanoma skin cancer; Eye color; Pigmentation; BASAL-CELL CARCINOMA; CUTANEOUS MALIGNANT-MELANOMA; HAIR COLOR; PIGMENTATION; GENE; METAANALYSIS; COHORT;
D O I
10.1007/s10552-021-01508-z
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common skin cancers. The incidence rates of all three types of skin cancers have increased in the past three decades. Light pigmentary traits have been recognized as one of the host risk factors for skin cancer, but findings on associations between eye colors and risk of skin cancers have been inconsistent. We performed a prospective analysis to examine the association between eye colors and risk of skin cancers using the Health Professionals Follow-up Study (HPFS). Cox proportional hazard models were applied to estimate relative risks (RRs) and their 95% confidence intervals (CIs). Effect modifications due to hair color and skin reaction to sun were also examined. The HPFS included 35,662 males. During a median follow-up of 19 years (1988-2012), 445 melanoma, 1123 SCC, and 7198 BCC cases were documented. Compared to those whose eye colors were dark or brown, participants with hazel/green/medium and blue/light colors had a 24% (RR = 1.24, 95% CI: 1.06-1.45) and a 19% (RR = 1.19, 95% CI: 1.01-1.41) higher risk of SCC, respectively. Similarly, a higher risk of BCC was observed in participants with hazel/green/medium eye colors (RR = 1.16, 95% CI: 1.09-1.23) and blue/light eye colors (RR = 1.17, 95% CI: 1.10-1.25). We did not find significant associations between eye color and risk of melanoma. Lighter eye color was associated with increased risks of SCC and BCC among those with dark hair colors (p for interaction <= 0.02). In conclusion, in this large prospective study of men, we found that light eye colors were associated with higher risks of SCC and BCC, but not melanoma. Further studies are needed to confirm this association in other populations.
引用
收藏
页码:109 / 116
页数:8
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