Synthesis, crystal structure, and anticancer properties of cyclic monocarbonyl analogs of curcumin

被引：21

作者：

Karthikeyan, Natesan Sundarmurthy ^{[1
]}

Sathiyanarayanan, Kulathu Iyer ^{[1
]}

Aravindan, Paduthapillai Gopal ^{[2
]}

Giridharan, P. ^{[3
]}

机构：

[1] VIT Univ, Div Chem, Sch Adv Sci, Vellore 632014, Tamil Nadu, India

[2] VIT Univ, Div Phys, Sch Adv Sci, Vellore 632014, Tamil Nadu, India

[3] Piramal Life Sci Ltd, Bombay 400063, Maharashtra, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2011年 / 20卷 / 01期

关键词：

2-Indanone; 1-Benzyl-4-piperidone; Aromatic aldehyde; Curcumin derivatives; Molecular docking; MONO-CARBONYL ANALOGS; CYTOTOXIC PROPERTIES; CELLS; TOXICITY; DESIGN;

D O I：

10.1007/s00044-009-9284-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel indan-2-one and dibenzylidenepiperidin-4-one compounds were synthesized and screened for anticancer activities. The compounds are symmetrical and they have conjugated double bonds. They closely resemble the curcumin analogs which are found to possess anticancer properties. The structure of the compounds was confirmed by single crystal study and wherever the compound is a powder, the structures were confirmed by spectral data (IR, NMR, and Mass).

引用

页码：81 / 87

页数：7

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