Anticancer perspectives of monocarbonyl analogs of curcumin: A decade (2014-2024) review

被引：4
|
作者：
Nagargoje, Amol A. [1 ,2 ]
Deshmukh, Tejshri R. [1 ]
Shaikh, Mubarak H. [1 ,3 ]
Khedkar, Vijay M. [4 ]
Shingate, Bapurao B. [1 ]
机构：
[1] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Chhatrapati Sambhajinagar 431004, Maharashtra, India
[2] Khopoli Municipal Council Coll, Dept Chem, Khopoli, Maharashtra, India
[3] Radhabai Kale Mahila Mahavidyalaya, Dept Chem, Ahmednagar, Maharashtra, India
[4] Vishwakarma Univ, Sch Pharm, Pune, Maharashtra, India
来源：
ARCHIV DER PHARMAZIE | 2024年 / 357卷 / 09期
关键词：
anticancer activity; curcumin; molecular docking study; monocarbonyl analogs of curcumin; structure-activity relationship; MONO-CARBONYL ANALOGS; SPECIES-MEDIATED APOPTOSIS; BIOLOGICAL EVALUATION; MULTIDRUG-RESISTANCE; MOLECULAR HYBRIDS; GASTRIC-CANCER; AGENTS DESIGN; LUNG-CANCER; CELL-DEATH; ANTIOXIDANT;
D O I：
10.1002/ardp.202400197
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Monocarbonyl analogs of curcumin (MACs) represent structurally modified versions of curcumin. The existing literature indicates that MACs exhibit enhanced anticancer properties compared with curcumin. Numerous research articles in recent years have emphasized the significance of MACs as effective anticancer agents. This review focuses on the latest advances in the anticancer potential of MACs, from 2014 to 2024, including discussions on their mechanism of action, structure-activity relationship (SAR), and in silico molecular docking studies. Monocarbonyl analogs of curcumin (MACs) are structurally modified versions of curcumin with improved biological activities. This review focuses on the anticancer attributes of MACs reported in the time frame between 2014 and 2024. The most active MACs from the literature are discussed with their structure-activity relationship (SAR) and mechanisms of action. image
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页数：28
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