Pro-inflammatory cytokines IL6, TNF-α, IL1β, procalcitonin, lipopotysaccharide binding protein and C-reactive protein in infective endocarditis

被引：42
|
作者：
Watkin, R. W.
Harper, L. V.
Vernallis, A. B.
Lang, S.
Lambert, P. A.
Ranasinghe, A. M.
Elliott, T. S. J.
机构：
[1] Aston Univ, Dept Pharmaceut & Biol Sci, Birmingham B4 7ET, W Midlands, England
[2] Glasgow Caledonian Univ, Sch Biol & Biomed Sci, Glasgow G4 0BA, Lanark, Scotland
[3] Queen Elizabeth Hosp, Queen Elizabeth Hosp, Dept Cardiothorac Surg, Birmingham B15 2TH, W Midlands, England
[4] Queen Elizabeth Hosp, Dept Clin Microbiol, Birmingham B15 2TH, W Midlands, England
来源：
JOURNAL OF INFECTION | 2007年 / 55卷 / 03期
关键词：
infective endocarditis; inflammatory markers; cytokines; acute phase proteins;
D O I：
10.1016/j.jinf.2007.05.174
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Objective: To evaluate the serum levels and diagnostic value of cytokines and acute phase proteins in patients with infective endocarditis (IE). Patients and methods: Serum samples from 63 patients diagnosed with IE and 71 control patients were analysed for the following markers: interleukin-6 (IL6), tumour necrosis factor-a (TNF-alpha), interleukin 1-beta (IL1 beta), procalcitonin (PCT), lipopolysaccharide binding protein (LBP) and C-reactive protein (CRP). Results: Serum levels of IL6, IL1 beta and CRP were significantly elevated in patients with IE as compared to controls. PCT, TNF-alpha,. and LBP were not elevated. Conclusion: Serum CRP and IL6 are elevated in IE. IL 6 may aid in establishing the diagnosis. There was no correlation between IL 6 levels and CRP, causative microorganism, echocardiographic features or outcome. (c) 2007 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：220 / 225
页数：6
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