Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT1A receptor in the caudal raphe region of the rat

被引:9
|
作者
Dodig, Ivana Pavlinac [1 ]
Pecotic, Renata [1 ]
Valic, Maja [1 ]
Dogas, Zoran [1 ]
机构
[1] Univ Split, Dept Neurosci, Sch Med, Split 21000, Croatia
关键词
long-term facilitation; phrenic nerve; respiratory plasticity; serotonin; sleep apnoea; RESPIRATORY PLASTICITY; GENOMIC CONSEQUENCES; EPISODIC HYPOXIA; NERVE ACTIVITY; HYPERCAPNIA; ACTIVATION; NUCLEUS; DETERMINANTS; SLEEP;
D O I
10.1111/j.1365-2869.2011.00948.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Obstructive sleep apnoea (OSA) is characterized by periods of upper airway collapse accompanied by repeated episodes of hypoxia. In experimental animals repeated bouts of hypoxia may evoke sustained augmentation of phrenic nerve activity, known as phrenic long-term facilitation (pLTF). This form of physiological compensation might contribute to stable breathing, minimizing the occurrence of apnoeas and/or hypopnoeas during sleep in patients with OSA. Serotonin (5-HT) has been shown to modulate respiratory neuronal activity, possibly via projections originating in the raphe nuclei. Our model focuses on the effects of 5-HT1A receptors blockade by selective antagonist WAY-100635 into the caudal raphe region on phrenic long-term facilitation after exposure to acute intermittent hypoxia (AIH) episodes. Adult, male, urethane-anaesthetized, vagotomized, paralyzed and mechanically ventilated SpragueDawley rats were exposed to AIH protocol. Experimental group received microinjection of WAY-100635 into the caudal raphe nucleus, whereas the control group received saline into the same site. Peak phrenic nerve activity and respiratory rhythm parameters were analysed during five hypoxic episodes, as well as at 15, 30 and 60 min after the end of hypoxias. In the control group, 1 h post-hypoxia pLTF was developed. Microinjections of selective 5-HT1A receptor antagonist WAY-100635 into the raphe nuclei prior to the AIH protocol prevented induction of pLTF. These results suggest that 5-HT1A receptor activation at supraspinal level is important for induction of pLTF, which is suggested to be an important respiratory neuroplasticity model in animal studies that possibly correlates with OSA in humans.
引用
收藏
页码:195 / 203
页数:9
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