Preparation and Evaluation of Modified Release Zidovudine Tablets

被引：0
|
作者：
Bicheri, Maria T. L. [1 ]
Chaud, Marco V. [1 ]
Goncalves, Marcos M. [2 ]
Vila, Marta M. D. C. [1 ,2 ]
机构：
[1] Univ Sorocaba, Postgrad Programs Pharmaceut Sci, BR-18023000 Sorocaba, SP, Brazil
[2] Univ Estadual Campinas, Univ Campinas, Inst Chem, Cidade Univ Zeferino Vaz, Campinas, SP, Brazil
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2011年 / 30卷 / 08期
关键词：
Hydroxypropyl methylcellulose; Modified release; Zidovudine;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Zidovudine is a drug used for the treatment of AIDS. The objective of this work was to prepare tablets for modified release of zidovudine. Hydroxypropyl methylcellulose HPMC K100LV and HPMC K4M at 1250 %, 18.75 % and 25.00 % were used. The tablets produced with 12.50 % of HPMC reached 100 % of the zidovudine release in 6 hours, while those produced with 18.75 and 25.00 %, released 24 h, following the Higuchi and First Order kinetic models, respectively. The calculated release exponent pointed out that formulations follow the anomalous type of release mechanism, with a combined phenomena of diffusion and erosion.
引用
收藏
页码：1512 / 1518
页数：7
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