Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes

被引：139

作者：

Tjwa, Marc ^{[1
,2
]}

Bellido-Martin, Lola ^{[3
]}

Lin, Yuan ^{[5
]}

Lutgens, Esther ^{[4
]}

Plaisance, Stephane ^{[1
,2
]}

Bono, Francoise ^{[6
]}

Delesque-Touchard, Nathalie ^{[6
]}

Herve, Caroline ^{[6
]}

Moura, Rute ^{[7
]}

Billiau, An D. ^{[5
]}

Aparicio, Cristina ^{[3
,8
]}

Levi, Marcel ^{[1
,2
]}

Daemen, Mat ^{[4
]}

Dewerchin, Mieke ^{[1
,2
]}

Lupu, Florea ^{[9
]}

Arnout, Jef ^{[7
]}

Herbert, Jean-Marc ^{[6
]}

Waer, Mark ^{[5
]}

de Frutos, Pablo Garcia ^{[3
,8
]}

DahlbAck, Bjoern ^{[8
]}

Carmeliet, Peter ^{[1
,2
]}

Hoylaerts, Marc F. ^{[7
]}

Moons, Lieve ^{[1
,2
]}

机构：

[1] Katholieke Univ Leuven, Ctr Transgene Technol & Gene Therapy, B-3000 Louvain, Belgium

[2] Flanders Inst Biotechnol VIB, Dept Transgene Technol & Gene Therapy, Louvain, Belgium

[3] CSIC, IDIBAPS, IIBB, Barcelona, Spain

[4] Univ Maastricht, Dept Pathol, Maastricht, Netherlands

[5] Katholieke Univ Leuven, Lab Expt Transplantat, Louvain, Belgium

[6] Cardiovasc Thrombosis Res Dept, Toulouse, France

[7] Katholieke Univ Leuven, Ctr Mol & Vasc Biol, Louvain, Belgium

[8] Lund Univ, Dept Clin Chem, Malmo, Sweden

[9] Oklahoma Med Res Fdn, Cardiovasc Res Program, Oklahoma City, OK 73104 USA

来源：

BLOOD | 2008年 / 111卷 / 08期

关键词：

D O I：

10.1182/blood-2007-05-089565

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The role of Gas6 in enclothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and enclothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart transplantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.

引用

页码：4096 / 4105

页数：10

共 50 条

[41] Gas6 deficiency prevents liver inflammation, steatohepatitis, and fibrosis in mice
Fourcot, Agnes
Couchie, Dominique
Chobert, Marie-Noele
Zafrani, Elie-Serge
Mavier, Philippe
Laperche, Yannick
Brouillet, Arthur
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2011, 300 (06): : G1043 - G1053
[42] TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis
van der Meer, Jonathan H. M.
van der Poll, Tom
van 't Veer, Cornelis
BLOOD, 2014, 123 (16) : 2460 - 2469
[43] ARACHIDONIC-ACID METABOLISM IN PLATELETS, LEUKOCYTES AND ENDOTHELIAL-CELLS
MARCUS, AJ
BROEKMAN, MJ
WEKSLER, BB
JAFFE, EA
SAFIER, LB
ULLMAN, HL
ISLAM, N
TACKGOLDMAN, K
HAEMOSTASIS, 1982, 12 (1-2) : 167 - 167
[44] Influence of polymorphonuclear leukocytes and platelets on the barrierfunction of cultured venular endothelial cells
Nees, S
Juchem, G
Fink, R
Arbogast, H
6TH WORLD CONGRESS FOR MICROCIRCULATION, 1996, : 401 - 404
[45] VASCULAR HEALING & BIORESORBABLE SCAFFOLDS: FROM PLATELETS, LEUKOCYTES TO ENDOTHELIAL CELLS
Tanguay, J-F
CARDIOLOGY, 2014, 128 : 321 - 321
[46] PADGEM - AN ADHESION RECEPTOR FOR LEUKOCYTES ON STIMULATED PLATELETS AND ENDOTHELIAL-CELLS
CELI, A
FURIE, B
FURIE, BC
PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1991, 198 (02): : 703 - 709
[47] THE ROLE OF LEUKOCYTE-ENDOTHELIAL INTERACTIONS IN THE ACCUMULATION OF LEUKOCYTES IN ALLERGIC INFLAMMATION
HASKARD, DO
LEE, TH
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 145 (02): : S10 - S13
[48] THE INTERACTIONS OF LIPIDS, PLATELETS AND ENDOTHELIAL-CELLS IN THROMBOGENESIS
NORDOY, A
ACTA MEDICA SCANDINAVICA, 1980, : 113 - 120
[49] INTERACTIONS OF ENDOTHELIAL CELLS, PLATELETS, AND MACROPHAGES - SESSION SUMMARY
BERLINER, JA
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1992, 56 (04): : 809 - 809
[50] Crosstalk between Akt and NF-κB pathway mediates inhibitory effect of gas6 on monocytes-endothelial cells interactions stimulated by P. gingivalis-LPS
Wang, Xuekui
Liu, Yingjun
Zhang, Shengnan
Ouyang, Xiangying
Wang, Yuguang
Jiang, Yong
An, Na
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 (14) : 7979 - 7990

← 1 2 3 4 5 →