Schizophrenia genes: characteristics of function and protein interaction networks

被引：1
|
作者：
Sun, Jingchun [1 ]
Han, Leng [2 ]
Zhao, Zhongming [1 ]
机构：
[1] Virginia Commonwealth Univ, Ctr Study Biol Complex, Dept Psychiat, Richmond, VA 23284 USA
[2] Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Peoples R China
来源：
BMEI 2008: PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND INFORMATICS, VOL 1 | 2008年
关键词：
D O I：
10.1109/BMEI.2008.227
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Schizophrenia is a heritable complex disease that involves multiple genes interacting themselves or with environment. Its genetic mechanisms have not been well understood. Currently, studies have revealed hundreds of genes associated with schizophrenia. This provides us an opportunity to explore the molecular characteristics of schizophrenia genes (SCZGenes) using genomics and systems biology approaches. In this study, we selected SCZGenes based on the published association studies and examined their functional features by comparing to the neurodevelopmental genes and control genes. We revealed that SCZGenes have strong correlation with neurodevelopment and other functional term. We further investigated the topological characteristics of SCZGenes in the human protein interaction network. We found that SCZGenes do not tend to encode hub proteins; rather they interact in a modest degree. Finally, we extracted SCZGenes subnetworks, which may be further analyzed with other information.
引用
收藏
页码：437 / +
页数：2
相关论文
共 50 条
  • [21] Discovering disease-associated genes in weighted protein-protein interaction networks
    Cui, Ying
    Cai, Meng
    Stanley, H. Eugene
    PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, 2018, 496 : 53 - 61
  • [22] Inferring protein function by domain context similarities in protein-protein interaction networks
    Song Zhang
    Hu Chen
    Ke Liu
    Zhirong Sun
    BMC Bioinformatics, 10
  • [23] Inferring protein function by domain context similarities in protein-protein interaction networks
    Zhang, Song
    Chen, Hu
    Liu, Ke
    Sun, Zhirong
    BMC BIOINFORMATICS, 2009, 10
  • [24] Collaboration-Based Function Prediction in Protein-Protein Interaction Networks
    Rahmani, Hossein
    Blockeel, Hendrik
    Bender, Andreas
    ADVANCES IN INTELLIGENT DATA ANALYSIS X: IDA 2011, 2011, 7014 : 318 - +
  • [25] Evolution and function of CAG/polyglutamine repeats in protein-protein interaction networks
    Schaefer, Martin H.
    Wanker, Erich E.
    Andrade-Navarro, Miguel A.
    NUCLEIC ACIDS RESEARCH, 2012, 40 (10) : 4273 - 4287
  • [26] Schizophrenia - Genes and environment function together
    不详
    PSYCHOPHARMAKOTHERAPIE, 2006, 13 (05): : 222 - 222
  • [27] Characteristics of hippocampal function in schizophrenia
    Tamminga, C
    Chin, RB
    Thomas, B
    NEUROPSYCHOPHARMACOLOGY, 2004, 29 : S15 - S16
  • [28] From Function to Interaction: A New Paradigm for Accurately Predicting Protein Complexes Based on Protein-to-Protein Interaction Networks
    Xu, Bin
    Guan, Jihong
    IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2014, 11 (04) : 616 - 627
  • [29] The use of protein-protein interaction networks for genome wide protein function comparisons and predictions
    Brun, C
    Baudot, A
    Guénoche, A
    Jacq, B
    METHODS IN PROTEOME AND PROTEIN ANALYSIS, 2004, : 103 - 124
  • [30] Prediction of Protein Function Using Gaussian Mixture Model in Protein-Protein Interaction Networks
    Koura, A. M.
    Kamal, A. H.
    Abdul-Rahman, I. F.
    INTERNATIONAL JOURNAL OF COMPUTER SCIENCE AND NETWORK SECURITY, 2010, 10 (04): : 114 - 119
12345