Phase 2 study of zolbetuximab plus mFOLFOX6 in claudin 18.2-positive locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma (G/GEJ): ILUSTRO cohort 2.

被引:6
|
作者
Klempner, Samuel J.
Lee, Keun-Wook
Metges, Jean-Philippe
Catenacci, Daniel V. T.
Loupakis, Fotios
Ilson, David H.
Shah, Manish A.
Shitara, Kohei
Arozullah, Ahsan
Park, Jung Wook
Raizer, Jeffrey J.
Bang, Yung-Jue
机构
[1] Massachusetts Gen Hosp, Boston, MA 02114 USA
[2] Seoul Natl Univ, Bundang Hosp, Coll Med, Seongnam, South Korea
[3] Hop Morvan, Ctr Hosp Reg Univ Brest, Brest, France
[4] Univ Chicago, Gastrointestinal Oncol Program, Chicago, IL 60637 USA
[5] Univ Azienda Osped Univ Pisana, Pisa, Italy
[6] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA
[7] Weill Cornell Med Coll, New York, NY USA
[8] Natl Canc Ctr Hosp East, Dept Gastrointestinal Oncol, Kashiwa, Chiba, Japan
[9] Astellas Pharma Global Dev Inc, Northbrook, IL USA
[10] Seoul Natl Univ, Coll Med, Seoul, South Korea
关键词
D O I
10.1200/JCO.2021.39.15_suppl.e16063
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
e16063
引用
收藏
页数:3
相关论文
共 50 条
  • [31] Andecaliximab/GS-5745 Alone and Combined with mFOLFOX6 in Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Results from a Phase I Study
    Shah, Manish A.
    Starodub, Alexander
    Sharma, Sunil
    Berlin, Jordan
    Patel, Manish
    Wainberg, Zev A.
    Chaves, Jorge
    Gordon, Michael
    Windsor, Kevin
    Brachmann, Carrie Baker
    Huang, Xi
    Vosganian, Greg
    Maltzman, Julia D.
    Smith, Victoria
    Silverman, Jeffrey A.
    Lenz, Heinz-Josef
    Bendell, Johanna C.
    CLINICAL CANCER RESEARCH, 2018, 24 (16) : 3829 - 3837
  • [32] Updated efficacy and safety results from phase III GLOW study evaluating zolbetuximab plus CAPOX as first-line (1L) treatment for patients with claudin-18 isoform 2-positive (CLDN18.2+), HER2L, locally advanced (LA) unresectable or metastatic gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma
    Lordick, F.
    Shah, M. A.
    Shitara, K.
    Ajani, J. A.
    Bang, Y-J.
    Enzinger, P. C.
    Ilson, D. H.
    van Cutsem, E.
    Gallego Plazas, J.
    Huang, J.
    Shen, L.
    Oh, S. C.
    Sunpaweravong, P.
    Soo, H. H. F.
    Turk, H. M.
    Park, J. W.
    Moran, D.
    Bhattacharya, P.
    Cao, Y. J.
    Xu, R-H.
    ANNALS OF ONCOLOGY, 2023, 34 : S1524 - S1524
  • [33] Global prevalence of claudin 18 isoform 2 in tumors of patients with locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma
    Shitara, Kohei
    Xu, Rui-Hua
    Ajani, Jaffer A.
    Moran, Diarmuid
    Guerrero, Abraham
    Li, Ran
    Pavese, Janet
    Matsangou, Maria
    Bhattacharya, Pranob
    Ueno, Yoko
    Wang, Xuewei
    Shah, Manish A.
    GASTRIC CANCER, 2024, 27 (05) : 1058 - 1068
  • [34] Prevalence of claudin-18 isoform 2 (CLDN18.2) positivity in locally advanced (LA) unresectable or metastatic gastric or gastroesophageal junction (mg/GEJ) adenocarcinoma in patients (pts) in the Asia region: Phase III SPOTLIGHT and GLOW studies
    Bang, Y-J.
    Shen, L.
    Kang, Y-K.
    Chao, Y.
    Soo, H. H. F.
    Sunpaweravong, P.
    Moran, D.
    Guerrero, A.
    Li, R.
    Pavese, J.
    Matsangou, M.
    Bhattacharya, P.
    Shitara, K.
    Xu, R-H.
    ANNALS OF ONCOLOGY, 2023, 34 : S1527 - S1528
  • [35] Phase 1b/2 study of margetuximab (M) plus pembrolizumab (P) in advanced HER2+gastroesophageal junction (GEJ) or gastric (G) adenocarcinoma (GEA).
    Catenacci, Daniel V. T.
    Park, Haeseong
    Lockhart, A. Craig
    Gold, Philip Jordan
    Enzinger, Peter C.
    Nordstrom, Jeffrey L.
    Hong, Sam
    Hochster, Howard S.
    Kelly, Ronan Joseph
    Uronis, Hope Elizabeth
    Bendell, Johanna C.
    Oh, Sang Cheul
    Park, Se Hoon
    Kim, Yeul Hong
    Kang, Yoon-Koo
    Lee, Keun-Wook
    Ng, Matthew C. H.
    Wigginton, Jon M.
    Davidson-Moncada, Jan Kenneth
    Bang, Yung-Jue
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (04)
  • [36] Health-related quality of life (hrqol) in patients with claudin18 isoform 2-positive (CLDN18.2+) locally advanced (LA) unresectable or metastatic gastric or gastroesophageal junction (mg/GEJ) adenocarcinoma: Results from SPOTLIGHT and
    Lordick, F.
    Van Cutsem, E.
    Shitara, K.
    Xu, R-H.
    Ajani, J. A.
    Shah, M. A.
    Oh, M.
    Ganguli, A.
    Rhoten, S.
    Bhattacharya, P.
    Matsangou, M.
    Park, J. W.
    Kang, Y-K.
    ANNALS OF ONCOLOGY, 2023, 34 : S860 - S861
  • [37] Management of nausea and vomiting (N/V) following first-line (1L) zolbetuximab plus chemotherapy treatment in claudin-18.2 (CLDN18.2)+, HER2-, locally advanced (LA) unresectable or metastatic gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma: Analysis from the phase 3 SPOTLIGHT and GLOW studies.
    Shitara, Kohei
    Pophale, Rupesh
    Matsangou, Maria
    Park, Jung Wook
    Oh, Mok
    Bhattacharya, Pranob P.
    Ranganath, Radhika
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (3_SUPPL) : 372 - 372
  • [38] Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first-line therapy in patients with locally advanced unresectable or metastatic gastric or gastroesophageal junction (G/GEJ) adenocarcinoma
    Xu, Rui-hua
    Arkenau, Hendrik-Tobias
    Bang, Yung-Jue
    Denlinger, Crystal S.
    Kato, Ken
    Tabernero, Josep
    Wang, Jin
    Li, Jiang
    Castro, Henry
    Moehler, Markus H.
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (04)
  • [39] Zolbetuximab plus gemcitabine and nab-paclitaxel (GN) in first-line treatment of claudin 18.2-positive metastatic pancreatic cancer (mPC): Phase 2, open-label, randomized study
    Park, Wungki
    O'Reilly, Eileen Mary
    Furuse, Junji
    Li, Chung-Pin
    Oh, Do-Youn
    Garcia-Carbonero, Rocio
    Roth, Gael
    Lee, Ho-Jin
    Kunieda, Futoshi
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [40] A phase II study of capecitabine-oxaliplatin and cetuximab in patients (pts) with advanced/metastatic gastric cancer (G) or gastroesophageal junction (GEJ) adenocarcinoma
    Iqbal, Syma
    El-Khoueiry, Anthony B.
    Yang, Dongyun
    Paez, David
    Duddalwar, Vinay
    Zhang, Wu
    Agafitei, Raluca Dana
    Lujan, Ramona
    Cole, Sarah
    Ning, Yan
    El-Khoueiry, Rita
    Loupakis, Fotios
    Wakatsuki, Takeru
    Lenz, Heinz-Josef
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)