Synthesis of Dibenzofurans via Palladium-Catalyzed Phenol-Directed C-H Activation/C-O Cyclization

被引：303

作者：

Xiao, Bin ^{[1
]}

Gong, Tian-Jun ^{[1
]}

Liu, Zhao-Jing ^{[1
]}

Liu, Jing-Hui ^{[1
]}

Luo, Dong-Fen ^{[1
]}

Xu, Jun ^{[1
]}

Liu, Lei ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Beijing 100084, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 24期

关键词：

N BOND FORMATION; ARYL HALIDES; DIRECT ARYLATION; DIARYL ETHERS; AMINATION REACTION; COUPLING REACTIONS; ROUTE; ACIDS; FUNCTIONALIZATION; 2-PHENYLPHENOLS;

D O I：

10.1021/ja203335u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A practical, Pd(0)/Pd(II)-catalyzed reaction was developed for phenol-directed C-H activation/C-O cyclization using air as an oxidant. The turnover-limiting step of the process was found to be C-O reductive elimination instead of C-H activation. This reaction can tolerate a variety of functional groups and is complementary to the previous methods for the synthesis of substituted dibenzofurans.

引用

页码：9250 / 9253

页数：4

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