On joint maximum-likelihood estimation of PCR efficiency and initial amount of target

被引：2
|
作者：
Vikalo, H. [1 ]
Hassibi, B. [1 ]
Hassibi, A. [1 ]
机构：
[1] CALTECH, Pasadena, CA 91125 USA
来源：
2006 IEEE INTERNATIONAL WORKSHOP ON GENOMIC SIGNAL PROCESSING AND STATISTICS | 2006年
关键词：
D O I：
10.1109/GENSIPS.2006.353149
中图分类号：
TP39 [计算机的应用];
学科分类号：
081203 ; 0835 ;
摘要：
We consider the problem of estimating unknown parameters of the real-time polymerase chain reaction (RTPCR) from noisy observations. The joint ML estimator of the RT-PCR efficiency and the initial number of DNA target molecules is derived. The mean-square error performance of the estimator is studied via simulations. The simulation results indicate that the proposed estimator significantly outperforms a competing technique.
引用
收藏
页码：47 / +
页数：2
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