Chronic hepatitis B in Italy: New features of an old disease - Approaching the universal prevalence of hepatitis B e antigen-negative cases and the eradication of hepatitis D infection

被引：48
|
作者：
Sagnelli, Evangelista [1 ]
Stroffolini, Tornmaso [2 ]
Mele, Alfonso [3 ]
Imparato, Michele [1 ]
Almasio, Piero L. [4 ]
机构：
[1] Univ Naples 2, Infect Dis Unit, Naples, Italy
[2] S Giacomo Hosp, Gastrointestinal Unit, Rome, Italy
[3] Ist Super Sanita, Clin Epidemiol Unit, Lab Epidemiol, I-00161 Rome, Italy
[4] Univ Palermo, Gastrointestinal Unit, Palermo, Italy
来源：
CLINICAL INFECTIOUS DISEASES | 2008年 / 46卷 / 01期
关键词：
D O I：
10.1086/524074
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We evaluated 1336 hepatitis B surface antigen-positive subjects consecutively observed in 79 Italian hospitals over a 6-month period. The proportion of hepatitis B e antigen-negative cases was 86.4%, that of patients coinfected with hepatitis D virus was 9.7%, and the rate of patients coinfected with hepatitis C virus was 16.8%. Multiple logistic regression analysis showed that age > 49 years, alcohol abuse, and anti-hepatitis D virus and anti-hepatitis C virus positivity were independent predictors of progression to liver cirrhosis.
引用
收藏
页码：110 / 113
页数：4
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