Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population

被引：25

作者：

Daimon, Makoto ^{[1
,2
]}

Sato, Hidenori ^{[3
]}

Oizumi, Toshihide ^{[1
]}

Toriyama, Sayumi ^{[3
]}

Saito, Takafumi ^{[2
]}

Karasawa, Shigeru ^{[1
]}

Jimbu, Yumi ^{[1
]}

Wada, Kiriko ^{[1
]}

Kameda, Wataru ^{[1
]}

Susa, Shinji ^{[1
]}

Yamaguchi, Hiroshi ^{[1
]}

Emi, Mitsuru ^{[3
]}

Muramatsu, Masaaki ^{[3
,4
]}

Kubota, Isao ^{[2
]}

Kawata, Sumio ^{[2
]}

Kato, Takeo ^{[1
,2
]}

机构：

[1] Yamagata Univ, Sch Med, Dept Neurol Hematol Metabol Endocrinol & Diabetol, Yamagata 9909585, Japan

[2] Yamagata Univ, Sch Med, 21st Century Ctr Excellence Program Study Grp, Yamagata, Japan

[3] HuBit Genom Res Inst, Tokyo, Japan

[4] Tokyo Med & Dent Univ, Med Res Inst, Dept Mol Epidemiol, Tokyo, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 365卷 / 03期

关键词：

PI3; kinase; PIK3C2G; quantitative association study; serum insulin levels; community-based study; haplotype and diplotype analysis;

D O I：

10.1016/j.bbrc.2007.10.180

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The associations of five SNPs (SNPsl-5: A-5468G, A-3333G, C-1794T, C437T and T9148C) of the class 11 phosphoinositide 3-kinase gamma-subunit (PIK3C2G) gene with type 2 diabetes were examined using a population of the Takahata Study (n (M/W): 2930 (1328/1602); age: 63.3 +/- 10.2 years), a Japanese community-based study. Quantitative association study of the SNPs with HbAlc levels showed significant association for SNPs 2 and 4 (p = 0.018 and 0.004, respectively). A case-control association study of SNP 4 with diabetes by multiple logistic regression analysis showed a significant association of the genotype TT of the SNP with an odds ratio of 2.21 (p = 0.001) independently of age, gender and BMI. In the NGT subjects, serum fasting insulin levels in the at-risk genotype group of SNP 4 were significantly lower than those in the others (TT, TC, and CC, 4.9 +/- 2.6, 5.4 +/- 3.0, and 5.6 +/- 3.4 mu U/ml, respectively; p = 0.029). (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：466 / 471

页数：6

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