An Evidence-Based Review of Related Metabolites and Metabolic Network Research on Cerebral Ischemia

被引：41
|
作者：
Liu, Mengting [1 ]
Tang, Liying [1 ]
Liu, Xin [1 ]
Fang, Jing [1 ]
Zhan, Hao [1 ]
Wu, Hongwei [1 ]
Yang, Hongjun [1 ]
机构：
[1] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China
来源：
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2016年 / 2016卷
基金：
中国国家自然科学基金;
关键词：
FREE FATTY-ACIDS; ARTERY OCCLUSION; BRAIN ISCHEMIA; BLOOD-FLOW; THROMBOEMBOLIC STROKE; CEREBROSPINAL-FLUID; MASS-SPECTROMETRY; HYPOXIA-ISCHEMIA; MILD HYPOTHERMIA; ANIMAL-MODEL;
D O I：
10.1155/2016/9162074
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In recent years, metabolomics analyses have been widely applied to cerebral ischemia research. This paper introduces the latest proceedings of metabolomics research on cerebral ischemia. The main techniques, models, animals, and biomarkers of cerebral ischemia will be discussed. With analysis help from the MBRole website and the KEGG database, the altered metabolites in rat cerebral ischemia were used for metabolic pathway enrichment analyses. Our results identify the main metabolic pathways that are related to cerebral ischemia and further construct ametabolic network. These results will provide useful information for elucidating the pathogenesis of cerebral ischemia, as well as the discovery of cerebral ischemia biomarkers.
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页数：12
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