Lipidomic Analysis to Assess Oxidative Stress in Acute Coronary Syndrome and Acute Stroke Patients

被引:13
|
作者
Maly, Martin [1 ,2 ]
Hajsl, Martin [1 ,2 ]
Bechynska, Kamila [3 ]
Kucerka, Ondrej [1 ,2 ]
Sramek, Martin [2 ,4 ]
Suttnar, Jiri [5 ]
Hlavackova, Alzbeta [5 ]
Hajslova, Jana [3 ]
Kosek, Vit [3 ]
机构
[1] Charles Univ Prague, Fac Med 1, Dept Med, Vojenske Nemocnice 1200, Prague 16900, Czech Republic
[2] Mil Univ Hosp, Vojenske Nemocnice 1200, Prague 16900, Czech Republic
[3] Univ Chem & Technol, Dept Food Chem & Anal, Tech 3, Prague 16628, Czech Republic
[4] Charles Univ Prague, Fac Med 1, Comprehens Stroke Ctr, Vojenske Nemocnice 1200, Prague 16900, Czech Republic
[5] Inst Hematol & Blood Transfus, Nemocnice 2094, Prague 12820, Czech Republic
关键词
acute coronary syndrome; stroke; plasma; lipidomics; high-resolution mass spectrometry; LIPOPROTEIN-LIPASE; HUMAN-PLASMA; IDENTIFICATION; METABOLOMICS; BIOMARKERS;
D O I
10.3390/metabo11070412
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Alterations in lipid metabolism mediated by oxidative stress play a key role in the process of atherosclerosis and superimposed thrombosis; these can lead to acute coronary syndrome (ACS) and acute ischemic stroke (AIS). Multiple studies have shown that the formation of atheromatous lesions is initiated by oxidation of low-density lipoproteins incorporated into the intima of the vessel wall. Here, we studied lipids in plasma samples from three cohorts: 61 patients with ACS (group A), 49 patients with AIS (group D), and 82 controls (group K). Untargeted lipidomics based on high-performance liquid chromatography coupled to mass spectrometry (UHPLC-HRMS) was employed to obtain comprehensive information on whether relationships exist between these patient categories based on lipid patterns. In addition, malondialdehyde (MDA) as a standard marker of oxidative stress was monitored. The most characteristic lipids in group K were fatty acyls of hydroxyfatty acids (FAHFAs). As expected, MDA concentrations were the lowest in group K. Our findings can better explain ongoing pathologies, both acute and chronic, with the potential for future diagnosis and treatment.
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页数:14
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