Genetic variants within miR-126 and miR-335 are not associated with breast cancer risk

被引：18

作者：

Yang, Rongxi ^{[1
,2
]}

Dick, Michelle ^{[1
,2
]}

Marme, Frederik ^{[1
]}

Schneeweiss, Andreas ^{[1
]}

Langheinz, Anne ^{[1
,2
]}

Hemminki, Kari ^{[3
,4
]}

Sutter, Christian ^{[5
]}

Bugert, Peter ^{[6
]}

Wappenschmidt, Barbara ^{[7
]}

Varon, Raymonda ^{[8
]}

Schott, Sarah ^{[1
]}

Weber, Bernhard H. F. ^{[9
]}

Niederacher, Dieter ^{[10
]}

Arnold, Norbert ^{[11
]}

Meindl, Alfons ^{[12
]}

Bartram, Claus R. ^{[5
]}

Schmutzler, Rita K. ^{[7
]}

Mueller, Heiko ^{[13
]}

Arndt, Volker ^{[13
]}

Brenner, Hermann ^{[13
]}

Sohn, Christof ^{[1
]}

Burwinkel, Barbara ^{[1
,2
]}

机构：

[1] Univ Heidelberg, Div Mol Biol Breast Canc, Dept Gynecol & Obstet, D-69120 Heidelberg, Germany

[2] Helmholtz Univ, Grp Mol Epidemiol, German Canc Res Ctr DKFZ, D-69120 Heidelberg, Germany

[3] German Canc Res Ctr, Div Mol Genet Epidemiol, D-69120 Heidelberg, Germany

[4] Karolinska Inst, Novum, Dept Biosci, S-14157 Huddinge, Sweden

[5] Univ Heidelberg, Inst Human Genet, D-69120 Heidelberg, Germany

[6] Univ Heidelberg, Med Fac Mannheim, Inst Transfus Med & Immunol, Red Cross Blood Serv Baden Wurttemberg Hessen, D-6800 Mannheim, Germany

[7] Univ Cologne, Div Mol Gynaecooncol, Dept Obstet & Gynaecol, Ctr Clin, D-50931 Cologne, Germany

[8] Humboldt Univ, Inst Human Genet, Charite, D-13353 Berlin, Germany

[9] Univ Regensburg, Inst Human Genet, D-93053 Regensburg, Germany

[10] Univ Dusseldorf, Div Mol Genet, Dept Obstet & Gynaecol, Ctr Clin, D-40225 Dusseldorf, Germany

[11] Univ Hosp Schleswig Holstein, Div Oncol, Dept Obstet & Gynaecol, D-24105 Kiel, Germany

[12] Tech Univ Munich, Dept Obstet & Gynaecol, Klinikum Rechts Isar, D-81675 Munich, Germany

[13] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2011年 / 127卷 / 02期

关键词：

Breast cancer; Polymorphism; miRNA; Genetic variants; SNP; MICRORNA; EXPRESSION; POLYMORPHISM; POPULATION; PROFILES; CLUSTER; MIRNA;

D O I：

10.1007/s10549-010-1244-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) are 20-22 nt non-coding RNAs which promote the degradation of target mRNAs or repression of the translation of mRNAs by sequence specific targeting. Many miRNAs are considered as oncogenes or tumor suppressors. MiR-126 and miR-335 play roles in the suppression of breast cancer metastasis by inhibiting tumor growth, proliferation, and cell invasion. The effects of SNPs within the two miRNAs are still unknown. In our study, we analyzed two SNPs, rs4636297 within miR-126 and rs41272366 within miR-335, in three study populations for a putative association with breast cancer risk. We compared the genotype and allele frequencies of rs4636297 and rs41272366 in 2854 cases versus 3188 controls of the three study populations independently and combined. None of the performed analyses showed statistically significant results. In conclusion, our data suggest that the two genetic variants within miR-126 and miR-335 are not associated with breast cancer risk.

引用

页码：549 / 554

页数：6

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