Bioactive Secondary Metabolites from Vincetoxicum stocksii

被引：0

作者：

Tousif, Muhammad Imran ^{[1
]}

Shazmeen, Natasha ^{[1
]}

Riaz, Naheed ^{[1
]}

Hussain, Hidayat ^{[2
]}

Al-Harrasi, Ahmed ^{[2
]}

Yaqoob, Asma ^{[1
]}

Nasim, Faiz-ul-Hassan ^{[1
]}

Jabbar, Abdul ^{[1
]}

Khatoon, Tasneem ^{[3
]}

Tareen, Rasool Bakhsh ^{[4
]}

Saleem, Muhammad ^{[1
]}

机构：

[1] Islamia Univ Bahawalpur, Dept Chem, Baghdad ul Jadeed Campus, Bahawalpur 63100, Pakistan

[2] Univ Nizwa, UoN Chair Omans Med Plants & Marine Nat Prod, POB 33, Birkat Al Mauz 616, Nizwa, Oman

[3] Univ Baluchistan, Dept Bot, Qutetta, Pakistan

[4] Govt Sadiq Women Coll Univ, Dept Chem, Bahawalpur 63100, Bahawalpur, Pakistan

来源：

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN | 2016年 / 38卷 / 02期

关键词：

Vincetoxicum stocksii; Secondary metabolites; Structure elucidation; Biological activity;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ethyl acetate soluble fraction of the methanolic extract of Vincetoxicum stocksii yielded four new compounds; vincetolate (1), vincetoside (2), vincetetrol (3) and vincetomine (4) along with seven know compounds; 1-(4-hydroxy-3-methoxyphenyl)-1,2,3,-propanetriol (5), feruloyl-6-O-beta-D-glucopyranoside (6), apocynin (7), 4-hydroxy-3,5-dimethoxybenzoic acid (8), 7-megastigmene-3,5,6,9-tetrol (9), qurcetin-3-O-beta-D-glucopyranoside (10) and 4'-methoxykaempferol-3-O-beta-D-glucopyranoside (11). The chemical structures of all the isolates were determined due to spectral analysis including sophisticated 1D- and 2D-NMR techniques and high resolution FABMS. Compounds 5-8 and 10 exhibited moderate to low antioxidant activity with IC50 values of 56.42 +/- 0.04-150 +/- 0.5 mu g/ml whereas, compounds 1, 5 and 8-11 showed significant antiurease activity with IC50 values in the range of 22.1 +/- 0.43-105.47 +/- 0.01 mu g/ml.

引用

页码：294 / 300

页数：7

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