Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants

被引：58
|
作者：
Jantan, I [1 ]
Rafi, IAA [1 ]
Jalil, J [1 ]
机构：
[1] Univ Kebangsaan Malaysia, Dept Pharm, Fac Allied Hlth Sci, Kuala Lumpur 50300, Malaysia
来源：
PHYTOMEDICINE | 2005年 / 12卷 / 1-2期
关键词：
platelet-activating factor (PAF); antagonistic activity; malaysian medicinal plants; Zingiberaceae sp; Cinnamomum sp;
D O I：
10.1016/j.phymed.2003.06.006
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Forty-nine methanol extracts of 37 species of Malaysian medicinal plants were investigated for their inhibitory effects on platelet-activating factor (PAF) binding to rabbit platelets, using H-3-PAF as a ligand. Among them, the extracts of six Zingiberaceae species (Alpinia galanga Swartz., Boesenbergia pandurata Roxb., Curcuma ochorrhiza Val., C. aeruginosa Roxb., Zingiber officinale Rose. and Z. zerumbet Koenig.), two Cinnamomum species (C. altissimum Kosterm. and C. pubescens Kochummen.), Goniothalamus malayanus Hook. f. Momordica charantia Linn. and Piper aduncum L. are potential sources of new PAF antagonists, as they showed significant inhibitory effects with IC50 values ranging from 1.2 to 18.4 mug ml(-1). (C) 2004 Elsevier GmbH. All rights reserved.
引用
收藏
页码：88 / 92
页数：5
相关论文
共 50 条
  • [41] Platelet-activating factor (PAF) and activity of its enzymes in heart failure patients
    Detopoulou, P.
    Nomikos, T.
    Fragopoulou, E.
    Antonopoulou, S.
    Panagiotakos, D.
    Kotrogiannis, I.
    Chrysohoou, C.
    Pitsavos, C.
    Stefanadis, C.
    FEBS JOURNAL, 2008, 275 : 341 - 341
  • [42] REDUCED INHIBITORY ACTIVITY TO PLATELET-ACTIVATING FACTOR (PAF) IN PLASMA OF DIABETIC SUBJECTS
    GIUSTOLISI, R
    MUSSO, R
    TRIOLO, A
    CACCIOLA, RR
    CACCIOLA, E
    THROMBOSIS AND HAEMOSTASIS, 1989, 62 (01) : 249 - 249
  • [43] PLATELET-ACTIVATING FACTOR (PAF) RECEPTOR ANTAGONIST TREATMENT INCREASES PROLIFERATION AND PROGENITOR MARKERS EXPRESSION IN RETINAL STEM CELLS
    Dalmaso, B.
    Del Debbio, C. B.
    CYTOTHERAPY, 2021, 23 (04) : 30 - 30
  • [44] Inhibition of PAF-induced platelet aggregation by WEB 2086 'in-vitro', an antagonist to the receptor for platelet-activating factor, in bovine.
    daSilva, MB
    Herion, F
    Raskinet, R
    David, JL
    Gustin, P
    Dessy, C
    Lekeux, P
    JOURNAL OF VETERINARY MEDICINE SERIES A-ZENTRALBLATT FUR VETERINARMEDIZIN REIHE A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINE, 1996, 43 (07): : 399 - 413
  • [45] BLEOMYCIN-INDUCED LUNG INJURY IN THE RAT - EFFECTS OF THE PLATELET-ACTIVATING FACTOR (PAF) RECEPTOR ANTAGONIST BN 52021 AND PLATELET DEPLETION
    EVANS, TW
    MCANULTY, RJ
    ROGERS, DF
    CHUNG, KF
    BARNES, PJ
    LAURENT, GJ
    ENVIRONMENTAL HEALTH PERSPECTIVES, 1990, 85 : 65 - 69
  • [46] Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF)
    Merlos, M
    Giral, M
    Balsa, D
    Ferrando, R
    Queralt, M
    Puigdemont, A
    GarciaRafanell, J
    Forn, J
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1997, 280 (01): : 114 - 121
  • [47] OCTYLONIUM BROMIDE, AN ANTAGONIST OF PLATELET-ACTIVATING FACTOR
    SUBISSI, A
    DELMONTE, M
    EVANGELISTA, S
    SANTICIOLI, P
    CRISCUOLI, M
    ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE, 1989, 302 : 255 - 267
  • [48] Prevention of alkali-induced corneal melting by a novel platelet-activating factor (PAF) antagonist
    Bazan, H
    He, J
    Bazan, NG
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 : U555 - U555
  • [49] PLATELET ACTIVATING FACTOR(PAF) ANTAGONISTS CONTAINED IN MEDICINAL-PLANTS - LIGNANS AND SESQUITERPENES
    IWAKAMI, S
    WU, JB
    EBIZUKA, Y
    SANKAWA, U
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, 40 (05) : 1196 - 1198
  • [50] CORRELATION OF PLATELET ACTIVATING FACTOR (PAF) RECEPTOR-BINDING WITH PAF-INDUCED SHAPE CHANGE IN HUMAN-PLATELETS - ROLE OF CALCIUM
    WINSLOW, CM
    KOWAL, AH
    SAUNDERS, RN
    AGENTS AND ACTIONS, 1985, 16 (06): : 636 - 636
12345