Ligand-Free Copper-Catalyzed Amination of Heteroaryl Halides with Alkyl- and Arylamines

被引：33

作者：

Liu, Zhen-Jiang ^{[2
]}

Vors, Jean-Pierre ^{[3
]}

Gesing, Ernst R. F. ^{[1
]}

Bolm, Carsten ^{[2
]}

机构：

[1] Bayer CropSci AG, BCS R I CI, D-40789 Monheim, Germany

[2] Rhein Westfal TH Aachen, Inst Organ Chem, D-52056 Aachen, Germany

[3] Bayer CropSci SAS, Ctr Rech La Dagoire, F-69009 Lyon, France

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 18期

关键词：

aminopyridines; aminopyrimidines; copper; N-heteroarylation; ligand-free conditions; LONG-LIVED CATALYSTS; C-N; ARYL HALIDES; INTRAMOLECULAR AMINATION; PALLADIUM; ARYLATION; EFFICIENT; SELECTIVITY; BROMIDES; MILD;

D O I：

10.1002/adsc.201000708

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

N-Heteroarylations of alkyl- and aryl-amines with various heteroaryl halides have been achieved by ligand-free copper-catalyzed cross-couplings affording aminopyridines and aminopyrimidines in moderate to high yields (up to 99% yield).

引用

页码：3158 / 3162

页数：5

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