Continuous Flow Synthesis of [Au(NHC)(Aryl)] (NHC=N-Heterocyclic Carbene) Complexes

被引：9

作者：

Cauwenbergh, Thibault ^{[1
,2
]}

Tzouras, Nikolaos, V ^{[1
,2
]}

Scattolin, Thomas ^{[1
,2
]}

Bhandary, Subhrajyoti ^{[1
,2
]}

Simoens, Andreas ^{[3
]}

Van Hecke, Kristof ^{[1
,2
]}

Stevens, Christian, V ^{[3
]}

Nolan, Steven P. ^{[1
,2
]}

机构：

[1] Univ Ghent, Dept Chem, Krijgslaan 281,S3, B-9000 Ghent, Belgium

[2] Univ Ghent, Ctr Sustainable Chem, Krijgslaan 281,S3, B-9000 Ghent, Belgium

[3] Univ Ghent, Dept Green Chem & Technol Synth, Biosources & Bioorgan Chem SynBioC Res Grp, Coupure Links 653, B-9000 Ghent, Belgium

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2021年 / 27卷 / 53期

基金：

比利时弗兰德研究基金会;

关键词：

continuous-flow synthesis; gold(I)-aryl; N-heterocyclic carbenes; sustainability; weak-base routes; TRANSMETALATION; REACTIVITY; GOLD(I); ROUTES;

D O I：

10.1002/chem.202102379

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of weak and inexpensive bases has recently opened promising perspectives towards the simpler and more sustainable synthesis of Au(I)-aryl complexes with valuable applications in catalysis, medicinal chemistry, and materials science. In recent years, continuous manufacturing has shown to be a reliable partner in establishing sustainable and controlled process scalability. Herein, the first continuous flow synthesis of a range of Au(I)-aryl starting from widely available boronic acids and various [Au(NHC)Cl] (NHC=N-heterocyclic carbene) complexes in unprecedentedly short reaction times and high yields is reported. Successful synthesis of previously non- or poorly accessible complexes exposed fascinating reactivity patterns. Via a gram-scale synthesis, convenient process scalability of the developed protocol was showcased.

引用

页码：13342 / 13345

页数：4

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