Continuous Flow Synthesis of [Au(NHC)(Aryl)] (NHC=N-Heterocyclic Carbene) Complexes

被引：9
|
作者：
Cauwenbergh, Thibault [1 ,2 ]
Tzouras, Nikolaos, V [1 ,2 ]
Scattolin, Thomas [1 ,2 ]
Bhandary, Subhrajyoti [1 ,2 ]
Simoens, Andreas [3 ]
Van Hecke, Kristof [1 ,2 ]
Stevens, Christian, V [3 ]
Nolan, Steven P. [1 ,2 ]
机构：
[1] Univ Ghent, Dept Chem, Krijgslaan 281,S3, B-9000 Ghent, Belgium
[2] Univ Ghent, Ctr Sustainable Chem, Krijgslaan 281,S3, B-9000 Ghent, Belgium
[3] Univ Ghent, Dept Green Chem & Technol Synth, Biosources & Bioorgan Chem SynBioC Res Grp, Coupure Links 653, B-9000 Ghent, Belgium
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2021年 / 27卷 / 53期
基金：
比利时弗兰德研究基金会;
关键词：
continuous-flow synthesis; gold(I)-aryl; N-heterocyclic carbenes; sustainability; weak-base routes; TRANSMETALATION; REACTIVITY; GOLD(I); ROUTES;
D O I：
10.1002/chem.202102379
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The use of weak and inexpensive bases has recently opened promising perspectives towards the simpler and more sustainable synthesis of Au(I)-aryl complexes with valuable applications in catalysis, medicinal chemistry, and materials science. In recent years, continuous manufacturing has shown to be a reliable partner in establishing sustainable and controlled process scalability. Herein, the first continuous flow synthesis of a range of Au(I)-aryl starting from widely available boronic acids and various [Au(NHC)Cl] (NHC=N-heterocyclic carbene) complexes in unprecedentedly short reaction times and high yields is reported. Successful synthesis of previously non- or poorly accessible complexes exposed fascinating reactivity patterns. Via a gram-scale synthesis, convenient process scalability of the developed protocol was showcased.
引用
收藏
页码：13342 / 13345
页数：4
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