Loss of heterozygosity of key tumor suppressor genes in advanced renal cancer patients treated with nivolumab

被引：3
|
作者：
Bersanelli, Melissa [1 ]
Gnetti, Letizia [2 ]
Azzoni, Cinzia [2 ]
Bottarelli, Lorena [2 ]
Sverzellati, Nicola [3 ]
Campanini, Nicoletta [2 ]
Varotti, Elena [2 ]
Corrado, Michele [3 ]
Parziale, Raffaele [3 ]
Rapacchi, Elena [1 ]
Caruso, Giuseppe [1 ]
Leonardi, Francesco [1 ]
Silini, Enrico Maria [2 ]
Buti, Sebastiano [1 ]
机构：
[1] Univ Hosp Parma, Med Oncol, Via Gramsci 14, I-43126 Parma, Italy
[2] Univ Hosp Parma, Pathol Anat Unit, Via Gramsci 14, I-43126 Parma, Italy
[3] Univ Hosp Parma, Radiol Unit, Via Gramsci 14, I-43126 Parma, Italy
来源：
IMMUNOTHERAPY | 2018年 / 10卷 / 09期
关键词：
FHIT; loss of heterozygosity; renal cell carcinoma; SPORADIC BREAST-CANCER; CLEAR-CELL CARCINOMA; MISMATCH-REPAIR; MICROSATELLITE INSTABILITY; OVARIAN-CANCER; BRCA2; VHL; 3P; TUMORIGENESIS; GUIDELINES;
D O I：
10.2217/imt-2017-0160
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Aim: We studied the possible clinical significance of loss of heterozygosity (LOH) at key tumor suppressor genes loci in advanced renal cancer patients treated with nivolumab. Methods: LOH study was performed on 3p14.2 (FHIT gene); 3p21.3-21.2; 9p21 (BDMF gene); 9p22 (SH3GL2 gene). Results: Of 12 patients, 8 (67%) had LOH. The most affected gene was FHIT. All five patients with LOH at FHIT locus had good outcome, mean progression free survival of 6.8 months. The patients LOH negative at FHIT locus had mean progression free survival of 4 months, 67% were treatment refractory. Overall, 75% of patients with LOH of at least one gene had benefit; 75% of LOH negative cases were refractory. Conclusion: LOH at key tumor suppressor genes should be further investigated as predictive for immunotherapy.
引用
收藏
页码：743 / +
页数：11
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