Isolation and structural elucidation of flibanserin as an adulterant in a health supplement used for female sexual performance enhancement

被引：15
|
作者：
Low, Min-Yong [1 ,2 ]
Li, Lin [1 ,2 ]
Ge, Xiaowei [2 ]
Kee, Chee-Leong [2 ]
Koh, Hwee-Ling [1 ]
机构：
[1] Natl Univ Singapore, Fac Sci, Dept Pharm, Singapore 117543, Singapore
[2] Hlth Sci Author, Appl Sci Grp, Div Pharmaceut, Singapore 169078, Singapore
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2012年 / 57卷
关键词：
Health supplement; Flibanserin; LC-LTQ Orbitrap XL FTMS; NMR; DESIRE DISORDER; DRUG;
D O I：
10.1016/j.jpba.2011.08.027
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A health supplement used for female sexual performance enhancement was sent to Health Sciences Authority of Singapore for testing. An unknown compound was detected and isolated from the health supplement and its structure was elucidated using LC-DAD, LC-FTMS, NMR and IR. The detected compound was identified to be flibanserin, a non-hormonal treatment developed for pre-menopausal woman with hypoactive sexual desire disorder (HSDD). (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：104 / 108
页数：5
相关论文
共 30 条
  • [21] Isolation and identification of hydroxythiohomosildenafil in herbal dietary supplements sold as sexual performance enhancement products
    Li, L.
    Low, M. -Y.
    Aliwarga, F.
    Teo, J.
    Ge, X. -W.
    Zeng, Y.
    Bloodworth, B. C.
    Koh, H. -L.
    FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2009, 26 (02): : 145 - 151
  • [22] Effect of adhesive on the performance of piezoelectric elements used to monitor structural health
    Qing, Xinlin P.
    Chan, Hian-Leng
    Beard, Shawn J.
    Ooi, Teng K.
    Marotta, Stephen A.
    INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES, 2006, 26 (08) : 622 - 628
  • [23] Physician Performance and Comfort Level With Addressing Female Sexual Health in Inflammatory Bowel Disease
    Chidi, Vivian N.
    Hess, Rachel
    Binion, David G.
    El-Hachem, Sandra
    GASTROENTEROLOGY, 2012, 142 (05) : S255 - S255
  • [24] Editorial: Bioactive natural products for health: isolation, structural elucidation, biological evaluation, structure-activity relationship, and mechanism
    Ma, Qinge
    Xiao, Hui
    Huang, Huilian
    Yuan, Chunsu
    Wei, Rongrui
    FRONTIERS IN CHEMISTRY, 2024, 12
  • [25] Chiral and achiral preparative SFC used as a workflow tool for the isolation of unknown trace impurities in consumer products for the purpose of the characterization and full structural elucidation of these impurities
    McCauley, John
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [26] Structural stigma and sexual orientation-related reproductive health disparities in a longitudinal cohort study of female adolescents
    Charlton, Brittany M.
    Hatzenbuehler, Mark L.
    Jun, Hee-Jin
    Sarda, Vishnudas
    Gordon, Allegra R.
    Raifman, Julia R. G.
    Austin, S. Bryn
    JOURNAL OF ADOLESCENCE, 2019, 74 : 183 - 187
  • [27] Determination of flibanserin and tadalafil in supplements for women sexual desire enhancement using high-performance liquid chromatography with tandem mass spectrometer, diode array detector and charged aerosol detector
    Poplawska, Magdalena
    Blazewicz, Agata
    Zolek, Paulina
    Fijalek, Zbigniew
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 94 : 45 - 53
  • [28] Family Rejection, Social Isolation, and Loneliness as Predictors of Negative Health Outcomes (Depression, Suicidal Ideation, and Sexual Risk Behavior) Among Thai Male-to-Female Transgender Adolescents
    Yadegarfard, Mohammadrasool
    Meinhold-Bergmann, Mallika E.
    Ho, Robert
    JOURNAL OF LGBT YOUTH, 2014, 11 (04) : 347 - 363
  • [29] Spirulina (Arthrospira platensis) Used as Functional Feed Supplement or Alternative Protein Source: A Review of the Effects of Different Dietary Inclusion Levels on Production Performance, Health Status, and Meat Quality of Broiler Chickens
    Lestingi, Antonia
    Alagawany, Mahmoud
    Di Cerbo, Alessandro
    Crescenzo, Giuseppe
    Zizzadoro, Claudia
    LIFE-BASEL, 2024, 14 (12):
  • [30] Ultrahigh-performance liquid chromatography-ion trap mass spectrometry characterization of the steroidal saponins of Dioscorea panthaica Prain et Burkill and its application for accelerating the isolation and structural elucidation of steroidal saponins
    Wang, Weihao
    Zhao, Ye
    Jing, Wenguang
    Zhang, Jun
    Xiao, Hui
    Zha, Qin
    Liu, An
    STEROIDS, 2015, 95 : 51 - 65
123