Isolation and structural elucidation of flibanserin as an adulterant in a health supplement used for female sexual performance enhancement

被引：15

作者：

Low, Min-Yong ^{[1
,2
]}

Li, Lin ^{[1
,2
]}

Ge, Xiaowei ^{[2
]}

Kee, Chee-Leong ^{[2
]}

Koh, Hwee-Ling ^{[1
]}

机构：

[1] Natl Univ Singapore, Fac Sci, Dept Pharm, Singapore 117543, Singapore

[2] Hlth Sci Author, Appl Sci Grp, Div Pharmaceut, Singapore 169078, Singapore

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2012年 / 57卷

关键词：

Health supplement; Flibanserin; LC-LTQ Orbitrap XL FTMS; NMR; DESIRE DISORDER; DRUG;

D O I：

10.1016/j.jpba.2011.08.027

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A health supplement used for female sexual performance enhancement was sent to Health Sciences Authority of Singapore for testing. An unknown compound was detected and isolated from the health supplement and its structure was elucidated using LC-DAD, LC-FTMS, NMR and IR. The detected compound was identified to be flibanserin, a non-hormonal treatment developed for pre-menopausal woman with hypoactive sexual desire disorder (HSDD). (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：104 / 108

页数：5

共 30 条

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