Synthesis of Heterocyclic Substituted Norcantharidin Derivatives

被引：2

作者：

Deng, Liping ^{[1
,2
]}

Yong, Zhang ^{[1
]}

Tao, Weifeng ^{[2
]}

Shen, Jianfeng ^{[3
]}

Wang, Wei ^{[2
]}

机构：

[1] Shaoxing Univ, Inst Chem & Chem Engn, Dept Pharmacol, Shaoxing 312000, Zhejiang, Peoples R China

[2] Zhejiang Supor Pharmaceut, Shaoxing 312000, Zhejiang, Peoples R China

[3] Zhejiang Zhenyuan Pharmaceut, Shaoxing 312000, Zhejiang, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2011年 / 48卷 / 04期

关键词：

MODIFIED CANTHARIDIN ANALOGS; TUMOR-CELL LINES; 5,6-DEHYDRONORCANTHARIDIN DERIVATIVES; ANTITUMOR ACTIVITIES; ANTICANCER ACTIVITY; GROWTH-INHIBITION; PANEL; 2A;

D O I：

10.1002/jhet.596

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Twenty novel norcantharidin derivatives, which were substituted by thiazole ring, were synthesized in a single step by the [3+2] 1,3-dipolar cycloaddition reaction with oxime or hydrazone in the presence of chloramine-T when compared with the conventional method.

引用

页码：808 / 813

页数：6

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