From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme

被引：81

作者：

Swenson, Samantha A. ^{[1
]}

Moore, Courtney M. ^{[2
]}

Marcero, Jason R. ^{[3
]}

Medlock, Amy E. ^{[3
,4
]}

Reddi, Amit R. ^{[2
,5
]}

Khalimonchuk, Oleh ^{[1
,6
,7
]}

机构：

[1] Univ Nebraska, Dept Biochem, Lincoln, NE 68588 USA

[2] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA

[3] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA

[4] Augusta Univ Univ Georgia Med Partnership, Athens, GA 30602 USA

[5] Georgia Inst Technol, Parker Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA

[6] Univ Nebraska, Nebraska Redox Biol Ctr, Lincoln, NE 68588 USA

[7] Fred & Pamela Buffett Canc Ctr, Omaha, NE 68105 USA

来源：

CELLS | 2020年 / 9卷 / 03期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

mitochondria; heme; porphyrin; heme biosynthesis; membrane transporters; hemoproteins; CYTOCHROME-C-OXIDASE; DELTA-AMINOLEVULINATE SYNTHASE; BLOOD-CELL MICROPARTICLES; SUCCINYL-COA SYNTHETASE; 5-AMINOLEVULINATE SYNTHASE; ASSEMBLY FACTOR; HUMAN FERROCHELATASE; LEIGH-SYNDROME; BIOSYNTHETIC-PATHWAY; CONSERVED RESIDUES;

D O I：

10.3390/cells9030579

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo-hemoproteins residing throughout the cell. While the biochemical aspects of heme biosynthetic reactions are well understood, the trafficking of newly synthesized heme-a highly reactive and inherently toxic compound-and its subsequent delivery to target proteins remain far from clear. In this review, we summarize current knowledge about heme biosynthesis and trafficking within and outside of the mitochondria.

引用

页数：36

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