A mutant single nucleotide polymorphism of follicle-stimulating hormone receptor is associated with a lower risk of endometriosis

被引:20
|
作者
Wang, Hsin-Shih [1 ,2 ]
Cheng, Bi-Hwa [2 ,3 ]
Wu, Hsien-Ming [1 ]
Yen, Chih-Feng [1 ,2 ]
Liu, Chun-Ting [4 ]
Chao, Angel [1 ]
Wang, Tzu-Hao [1 ,4 ]
机构
[1] Chang Gung Univ, Chang Gung Mem Hosp, Dept Obstet & Gynecol, Lin Kou Med Ctr, Tao Yuan, Taiwan
[2] Chang Gung Univ, Coll Med, Grad Inst Clin Med Sci, Tao Yuan, Taiwan
[3] Chang Gung Mem Hosp, Kaohsiung Med Ctr, Dept Obstet & Gynecol, Kaohsiung, Taiwan
[4] Chang Gung Mem Hosp, Genom Med Res Core Lab, Tao Yuan, Taiwan
关键词
Endometriosis; single nucleotide polymorphism (SNP); matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS);
D O I
10.1016/j.fertnstert.2010.07.1092
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Six hundred thirty-seven Taiwanese Chinese women including 300 patients with endometriosis and 337 controls without endometriosis were enrolled to investigate the association between nonsynonymous single nucleotide polymorphism of the FSH receptor gene and the risk of endometriosis. For the A/G polymorphism of FSH receptor gene (Asn680Ser), a univariate analysis for women with endometriosis demonstrated that both the GG genotype (680(Ser/Ser)) and GA genotype (680(Ser/Asn)) were associated with a significantly lower risk of endometriosis. (Fertil Steril (R) 2011;95:455-7. (C) 2011 by American Society for Reproductive Medicine.)
引用
收藏
页码:455 / 457
页数:3
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