Mechanism of sustained drug release in diffusion-controlled polymer matrix-application of percolation theory

被引：1

作者：

Xu, TW ^{[1
]}

He, BL ^{[1
]}

机构：

[1] Nankai Univ, Inst Polymer Chem, Tianjin 300071, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1998年 / 170卷 / 02期

关键词：

controlled release; percolation threshold; pore diffusion; matrix diffusion; poly(ethylene-vinylalcohol);

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This paper dealt with the controlled release of two kinds of drugs, 5-fluorouracil (5-FU) and hydrocortisonum (Hydro.) and loaded poly(ethylene-vinplalcohol) (EVAL), which composed 5-FU/EVAL and Hydro./EVAL matrix systems. The results were analyzed using the pseudo-steady-diffusion models coupled with the fundamental concepts of percolation theory. The percolation thresholds for the two systems were calculated, which could indicate the contribution of pore and matrix diffusion in controlled drug release. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：139 / 149

页数：11

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