Eliminating Ovarian Cancer Stem Cells: A Potential Therapeutic Target for Ovarian Cancer Chemoresistance

被引：19
|
作者：
Wang, Xiaohui [1 ]
Li, Xiaolei [1 ]
Fu, Xiaoyu [2 ]
Bai, Miaomiao [1 ]
Li, Xiang [1 ]
Mei, Qian [1 ]
Nie, Jing [1 ]
Wu, Zhiqiang [1 ]
Han, Weidong [1 ]
机构：
[1] Chinese Peoples Liberat Army Gen Hosp, Sch Life Sci, Inst Basic Med, Dept Mol Biol, Beijing 100853, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Obstet & Gynecol, Beijing 100853, Peoples R China
来源：
CURRENT PROTEIN & PEPTIDE SCIENCE | 2015年 / 16卷 / 04期
基金：
中国国家自然科学基金;
关键词：
OCSCs; ovarian cancer; chemoresistance; therapeutic target; MULLERIAN-INHIBITING SUBSTANCE; TUMOR-INITIATING CELLS; PULSED DENDRITIC CELLS; ACUTE MYELOID-LEUKEMIA; SIDE-POPULATION; ALDEHYDE DEHYDROGENASE; BREAST-CANCER; MALIGNANT GLIOMA; IMMUNE-RESPONSE; PROSTATE-CANCER;
D O I：
10.2174/138920371604150429151457
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumor recurrence followed by chemoresistance is a major cause of the poor survival rates for ovarian cancer. Despite advances in ovarian cancer chemotherapies and increased knowledge of the characteristics of ovarian cancer, chemoresistance is still an enormous clinical challenge. Current research suggests that ovarian cancer stem cells (OCSCs) might be involved in the occurrence of chemoresistance in ovarian cancer. In this review, we focus on the relationship of ovarian cancer stem cells with drug-resistant ovarian cancer phenotypes. We also discuss the current knowledge regarding ovarian cancer stem cell-based therapeutic strategies as attempts to overcome chemoresistance, the largest obstacle for successful treatment. Finally, we discuss methods for improving the treatment outcomes of ovarian cancer patients with chemoresistance.
引用
收藏
页码：270 / 278
页数：9
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