Sodium fusidate in Guillain-Barre syndrome: a case report

被引：11
|
作者：
Nicoletti, F
Nicoletti, A
Giuffrida, S
Di Marco, R
Meroni, P
Bendtzen, K
Lunetta, M
机构：
[1] Univ Milan, Inst Microbiol, I-20122 Milan, Italy
[2] Catania Univ, Neurol Inst, Catania, Italy
[3] Catania Univ, Inst Microbiol, Catania, Italy
[4] IRCCS Policlin, Milan, Italy
[5] Natl Univ Hosp, RHIMA Ctr Rigshosp, Inst Inflammat Res, Copenhagen, Denmark
[6] Catania Univ, Inst Internal Med Endocrinol & Metab, Catania, Italy
来源：
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1998年 / 65卷 / 02期
关键词：
autoimmunity; cytokines; Fucidin; Guillain-Barre syndrome;
D O I：
10.1136/jnnp.65.2.266
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A patient with Guillain-Barre syndrome is reported on who responded favourably to a short course treatment with the novel immunosuppressant sodium fusidate (Fucidin), given at a daily dose of 1.5 g for one week. Along with prompt and clear cut clinical improvement, treatment with Fucidin was associated with a rapid decline in the blood concentrations of inflammatory cytokines presumably implicated in the pathogenesis of Guillain-Barre syndrome such as interleukin-2, interferon-gamma, and tumor necrosis factor-a. The ex vivo production of these cytokines was also markedly diminished compared with pretreatment values. Fucidin was well tolerated and no clinical or biochemical side effects were seen.
引用
收藏
页码：266 / 268
页数：3
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