Molecular endocrinology and physiology of the aging central nervous system

被引：94
|
作者：
Smith, RG
Betancourt, L
Sun, YX
机构：
[1] Baylor Coll Med, Huffington Ctr Aging, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Med, Houston, TX 77030 USA
来源：
ENDOCRINE REVIEWS | 2005年 / 26卷 / 02期
关键词：
D O I：
10.1210/er.2002-0017
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aging is associated with a progressive decline in physical and cognitive functions. The impact of age-dependent endocrine changes regulated by the central nervous system on the dynamics of neuronal behavior, neurodegeneration, cognition, biological rhythms, sexual behavior, and metabolism are reviewed. We also briefly review how functional deficits associated with increases in glucocorticoids and cytokines and declining production of sex steroids, GH, and IGF are likely exacerbated by age-dependent molecular misreading and alterations in components of signal transduction pathways and transcription factors.
引用
收藏
页码：203 / 250
页数：48
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