Fixed-parameter algorithms in phylogenetics

被引:17
|
作者
Gramm, Jens [2 ]
Nickelsen, Arfst [1 ]
Tantau, Till [1 ]
机构
[1] Med Univ Lubeck, Inst Theoret Informat, Lubeck, Germany
[2] Univ Tubingen, Wilhelm Schickard Inst Informat, D-72074 Tubingen, Germany
来源
COMPUTER JOURNAL | 2008年 / 51卷 / 01期
关键词
bioinformatics; phylogenetics algorithms; parameterized algorithms;
D O I
10.1093/comjnl/bxm049
中图分类号
TP3 [计算技术、计算机技术];
学科分类号
0812 ;
摘要
We survey the use of fixed-parameter algorithms in the field of phylogenetics, which is the study of evolutionary relationships. The central problem in phylogenetics is the reconstruction of the evolutionary history of biological species, but its methods also apply to linguistics, philology or architecture. A basic computational problem is the reconstruction of a likely phylogeny ( genealogical tree) for a set of species based on observed differences in the phenotype like color or form of limbs, based on differences in the genotype like mutated nucleotide positions in the DNA sequence, or based on given partial phylogenies. Ideally, one would like to construct socalled perfect phylogenies, which arise from a very simple evolutionary model, but in practice one must often be content with phylogenies whose 'distance from perfection' is as small as possible. The computation of phylogenies has applications in seemingly unrelated areas such as genomic sequencing and finding and understanding genes. The numerous computational problems arising in phylogenetics often are NP-complete, but for many natural parametrizations they can be solved using fixed-parameter algorithms.
引用
收藏
页码:79 / 101
页数:23
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