Diagnostic Accuracy of Different Soluble fms-Like Tyrosine Kinase 1 and Placental Growth Factor Cut-Off Values in the Assessment of Preterm and Term Preeclampsia: A Gestational Age Matched Case-Control Study

被引:15
|
作者
Huhn, Evelyn A. [1 ]
Kreienbuhl, Andrea [1 ]
Hoffmann, Ina [1 ]
Schoetzau, Andreas [1 ]
Lange, Soeren [2 ]
de Tejada, Begona Martinez [3 ,4 ]
Hund, Martin [5 ]
Hoesli, Irene [1 ]
Lapaire, Olav [1 ]
机构
[1] Univ Hosp Basel, Dept Obstet & Gynecol, Basel, Switzerland
[2] Inst Hosp Nord Vaudois, Dept Obstet & Gynecol, Yverdon, Switzerland
[3] Univ Geneva, Geneva Univ Hosp, Dept Obstet & Gynecol, Geneva, Switzerland
[4] Univ Geneva, Fac Med, Geneva, Switzerland
[5] Roche Diagnost Int, Rotkreuz, Switzerland
关键词
preeclampsia; hypertension in pregnancy; diagnosis; biomarker; sFlt-1; PlGF; sFlt-1:PlGF ratio; INTERNATIONAL-SOCIETY; ANGIOGENIC FACTORS; FACTOR RATIO; PREGNANCY; HYPERTENSION; PREDICTION; WOMEN; RISK;
D O I
10.3389/fmed.2018.00325
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: The objective was to investigate the diagnostic accuracy of different thresholds of the soluble vascular endothelial growth factor receptor-1 (sFlt-1) and the placental growth factor (PlGF) in preterm (<= 37 weeks) and term (>37 weeks) preeclampsia (PE). Materials and Methods: A nested case-control study was performed from a high-risk Swiss cohort. Only blood samples on the day of PE diagnosis were included. The primary outcome was to verify the diagnosis using the recently proposed cut-off values for PE (sFlt-1:PlGF ratio of >= 85 in <= 34 weeks or >= 110 in >34 weeks), and the gestational age dependent centiles. Results: Thirty-four women with preterm PE were matched with 64 controls and 25 women with term PE with 45 controls. The test performance of the sFlt-1:PlGF ratio in preterm PE was very good (AUROCC of 0.95). The sFlt-1:PlGF ratio could adequately predict adverse fetal or neonatal outcome. In term PE, sFlt-1 alone showed a slightly better diagnostic accuracy with an AUROCC of 0.84. Almost all women with a sFlt-1:PlGF ratio above threshold delivered during the following week. Discussion: In pregnant women with high risk of developing PE, the sFlt-1:PlGF ratio and sFlt-1 levels help clinicians to confirm the diagnosis of imminent preterm PE and can additionally be used to rule out PE at term.
引用
收藏
页数:11
相关论文
共 50 条
  • [31] Omeprazole Administration To Women With Preterm Preeclampsia: Effects On Circulating Soluble Fms-like Tyrosine Kinase-1, Placental Growth Factor And Endothelin-1 Secretion
    Rugina, Neuman, I
    Visser, Willy
    Jan, Danser H.
    HYPERTENSION, 2021, 78
  • [32] Diagnosing preeclampsia using soluble fms-like tyrosine kinase-1 and placental growth factor levels measured by the Abbott ARCHITECT
    Lim, Kee-Hak
    Karumanchi, S. Ananth
    Laird, Don M.
    Sluss, Patrick
    Pucci, Dominick L.
    Sogin, David C.
    OBSTETRICS AND GYNECOLOGY, 2008, 111 (04): : 50S - 51S
  • [33] Serum soluble FMS-like tyrosine kinase 1 and placental growth factor concentration as predictors of preeclampsia in high risk pregnant women
    Hanita, O.
    Alia, N. N.
    Zaleha, A. M.
    Azlin, M. I. Nor
    MALAYSIAN JOURNAL OF PATHOLOGY, 2014, 36 (01) : 19 - 26
  • [34] Placental growth factor, soluble fms-like tyrosine kinase 1 and progesterone as diagnostic biomarkers for ectopic pregnancy and missed abortion
    Martinez-Ruiz, Ana
    Desamparados Sarabia-Meseguer, Maria
    Perez-Fornieles, Joaquin
    Antonio Vilchez, Juan
    Tovar-Zapata, Isabel
    Antonio Noguera-Velasco, Jose
    CLINICAL BIOCHEMISTRY, 2014, 47 (09) : 844 - 847
  • [35] Placental Growth Factor, Soluble fms-Like Tyrosine Kinase 1, Soluble Endoglin, IL-6, and IL-16 as Biomarkers in Preeclampsia
    Radulescu, Carmen
    Bacarea, Anca
    Hutanu, Adina
    Gabor, Rozalia
    Dobreanu, Minodora
    MEDIATORS OF INFLAMMATION, 2016, 2016
  • [36] Prediction of Preeclampsia Using the Soluble fms-Like Tyrosine Kinase 1 to Placental Growth Factor Ratio: A Prospective Cohort Study of Unselected Nulliparous Women
    Sovio, Ulla
    Gaccioli, Francesca
    Cook, Emma
    Hund, Martin
    Charnock-Jones, D. Stephen
    Smith, Gordon C. S.
    HYPERTENSION, 2017, 69 (04) : 731 - 738
  • [37] Establishing reference values for both total soluble fms-like tyrosine kinase 1 and free placental growth factor in pregnant women
    Hirashima, C
    Ohkuchi, A
    Arai, F
    Takahashi, K
    Suzuki, H
    Watanabe, T
    Kario, K
    Matsubara, S
    Suzuki, M
    HYPERTENSION RESEARCH, 2005, 28 (09) : 727 - 732
  • [38] Establishing Reference Values for Both Total Soluble Fms-Like Tyrosine Kinase 1 and Free Placental Growth Factor in Pregnant Women
    Chikako Hirashima
    Akihide Ohkuchi
    Fujimi Arai
    Kayo Takahashi
    Hirotada Suzuki
    Takashi Watanabe
    Kazuomi Kario
    Shigeki Matsubara
    Mitsuaki Suzuki
    Hypertension Research, 2005, 28 : 727 - 732
  • [39] The preeclampsia biomarkers soluble fms-like tyrosine kinase-1 and placental growth factor: current knowledge, clinical implications and future application
    Lapaire, Olav
    Shennan, Andrew
    Stepan, Holger
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2010, 151 (02) : 122 - 129
  • [40] Ratio of soluble fms-like tyrosine kinase 1 to placental growth factor predicts time to delivery and mode of birth in patients with preeclampsia: a letter
    Sarkar, Avir
    Lanjewar, Prathamesh
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2025, 232 (01) : e20 - e20