Synthesis of N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3-H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as potential dual inhibitor DHFR and TS.

被引：0

作者：

Gangjee, A

Lin, X

McGuire, JJ

Kisliuk, RL

机构：

[1] Duquesne Univ, Sch Pharmaceut Chem, Div Med Chem, Pittsburgh, PA 15282 USA

[2] Roswell Pk Canc Inst, Grace Canc Drug Ctr, Buffalo, NY USA

[3] Tufts Univ, Sch Med, Dept Biochem, Medford, MA 02155 USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 225卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

135-MEDI

引用

页码：U198 / U198

页数：1

共 50 条

[31] SYNTHESIS OF THE PENTA-GLUTAMYL DERIVATIVE OF N-[4-]N-[3-(2,4-DIAMINO-1,6-DIHYDRO-6-OXO-5-PYRIMIDINYL)-PROPYL]AMINO]BENZOYL]-L-GLUTAMIC ACID (5-DACTHF) - AN ACYCLIC ANALOG OF TETRAHYDROFOLIC ACID
STYLES, VL
KELLEY, JL
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1990, 27 (06) : 1809 - 1813
[32] SYNTHESIS OF N-[P-[[(2-AMINO-3,4-DIHYDRO-4-THIOXO-6-PTERIDINYL)METHYL]-METHYLAMINO]BENZOYL]-L-GLUTAMIC ACID (N10-METHYL-4-THIOFOLIC ACID) AND RELATED COMPOUNDS
ELLIOTT, RD
TEMPLE, C
FRYE, JL
MONTGOMERY, JA
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1973, 10 (06) : 1071 - 1072
[33] Synthesis of N-{[4-(2-amino-4(3H)-oxo-5,6,7,8-tetrahydro-(9H)-pyrimido[4,5-b]-azepin-6-yl)methyl]benzoyl}-L-glutamic acid and two of its conformationally-restricted analogs
Read, MW
Miller, ML
Ray, PS
TETRAHEDRON, 1999, 55 (02) : 373 - 392
[34] EARLY CLINICAL-STUDIES WITH CB3717 ((N-(4-(N-(2-AMINO-4-HYDROXY-6-QUINAZOLINYL)METHYL)PROP-2-YNYLAMINO)BENZOYL)-L-GLUTAMIC ACID
CALVERT, AH
ALISON, DL
WILTSHAW, E
BAKER, JW
ROBINSON, B
MOONEY, C
MCELWAIN, TJ
HARRAP, KR
PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1984, 25 (MAR): : 165 - 165
[35] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF AN ACYCLIC ANALOG OF 5,6,7,8-TETRAHYDROFOLIC ACID, N-[4-[[3-(2,4-DIAMINO-1,6-DIHYDRO-6-OXO-5-PYRIMIDINYL)PROPYL]AMINO]-BENZOYL]-L-GLUTAMIC ACID
KELLEY, JL
MCLEAN, EW
COHN, NK
EDELSTEIN, MP
DUCH, DS
SMITH, GK
HANLON, MH
FERONE, R
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (02) : 561 - 567
[36] Chemoenzymatic preparation of the novel antifolate thymidylate synthase inhibitor N-(4-{N-[(6S)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta [g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}-benzoyl)-L-glutamic acid and its glutamyl cleavage product
Marriott, JH
Neidle, S
Matusiak, Z
Bavetsias, V
Jackman, AL
Melin, C
Boyle, FT
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1999, (11): : 1495 - 1503
[37] Design and synthesis of N-[4-(2,4-diamino-5-ethylpyrrolo[2,3-dipyrimidin-6-yl)thioibenzoyl]-L-glutamic acid as an antitumor agent.
Gangjee, A
Zeng, YB
McGuire, JJ
Kisliuk, RL
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 225 : U191 - U191
[38] PHARMACOKINETIC STUDIES IN HUMANS WITH CB3717 (N-(4-(2-AMINO-4-HYDROXY-6-QUINAZOLINYL)METHYL)PROP-2-YNYLAMINO)BENZOYL)-L-GLUTAMIC ACID)
ALISON, DL
NEWELL, DR
CALVERT, AH
BRITISH JOURNAL OF CANCER, 1983, 48 (01) : 126 - 127
[39] 6-(4-Amino-1-methyl-2-(methylthio)-6-oxo-1,6-dihydro-pyrimidin-5-yl)-3,6-dimethyl-2-(methylthio)-6,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-4,5-dione
Romo, Pablo E.
Quiroga, Jairo
Insuasty, Braulio
Nogueras, Manuel
Cobo, Justo
MOLBANK, 2015, (01)
[40] 7-DEAZAPURINES .5. SYNTHESIS AND REACTIONS OF 7-AMINO-5,7-DIHYDRO-4-METHYL-2-PHENYL-6H-PYRROLO[2,3-D]PYRIMIDIN-6-ONE
SANTILLI, AA
SCOTESE, AC
KIM, DH
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1975, 12 (06) : 1291 - 1293

← 1 2 3 4 5 →