HLA class II involvement in HIV-associated Toxoplasmic encephalitis development

A total of 220 individuals were included in this study, 112 HIV-seronegative healthy individuals and 108 HIV-1-infected patients involving: 18 AIDS patients with Toxoplasmic encephalitis (AIDS-TE), 49 AIDS patients Without TE, and 41 asymptomatic patients, were genotyping for DR and DQ loci by rnolecular biology techniques. Fisher's Exact test was used for statistical analysis. HLA-DQB*0402 and DRBI*08 alleles were associated with a high risk to develop opportunistic infections with neurological involvement, mainly Toxoplasina encephalitis in relationship with subjects healthy (OR = 20.43; Pc = 7.0 x 10(-6) and OR = 11; Pc = 2.6 x 10(-4) respectively); in relationship with AIDS no TE (OR = 6.98; Pc = 0.028 and OR = 4.85; P = 0.0 12, Pc = 0. 14) and with patients in asymptomatic stage (OR = 61.50, Pc = 8.4 x 10(-6) and OR = 19.38; Pc = 3.9 x 10(-4)), respectively. Conclusions. It was concluded that the presence of HLA-DQB*0402 and DRBI*08 alleles in HIV-1-positive patients could be considered risk factors for developing neurological opportunistic infections, mainly Toxoplasinic encephalitis. (c) 2005 Elsevier Inc. All rights reserved.