TLC Analysis of Twelve Different Salts of Oxime HI-6-Reactivator of Nerve Agent Inhibited AChE

被引：0

作者：

Jun, Daniel ^{[1
]}

Stodulka, Petr ^{[1
]}

Hrabinova, Martina ^{[1
]}

Pohanka, Miroslav ^{[1
]}

Dolezal, Bohuslav ^{[2
]}

Kuca, Kamil ^{[1
]}

机构：

[1] Natl Def Univ, Fac Mil Hlth Sci, Ctr Adv Studies, Hradec Kralove 50001, Czech Republic

[2] Vakos XT As, Prague, Czech Republic

来源：

JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC | 2011年 / 24卷 / 02期

关键词：

TLC; HI-6; Salt; Oxime; Antidote; Reactivation; PYRIDINIUM ALDOXIMES; ACETYLCHOLINESTERASE REACTIVATORS; HI-6; DIMETHANESULFONATE; (E)-BUT-2-ENE LINKER; ANTIDOTES; PROPHYLAXIS; DICHLORIDE; DIAGNOSIS; EFFICACY;

D O I：

10.1556/JPC.24.2011.2.3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Four thin-layer chromatographic (TLC) methods for identification of twelve bisquaternary acetylcholinesterase reactivator HI-6 salts (sulfate, chloride, acetate, bromide, phosphate, mesylate, tartrate, iodide, malonate, salicylate, maleinate, and tosylate) are described. By use of TLC, particular E and Z isomers of each salt on the oxime group were also separated. These TLC methods could be of high interest for rapid identification of each salt and for purity control.

引用

页码：105 / 107

页数：3

共 13 条

[11] Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6
Seeger, T.
Niessen, K. V.
Langer, P.
Gerhardus, J.
Worek, F.
Friess, H.
Bumm, R.
Mihaljevic, A. L.
Thiermann, H.
TOXICOLOGY LETTERS, 2011, 206 (01) : 72 - 76
[12] Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents
Giacoppo, Juliana O. S.
Franca, Tanos C. C.
Kuca, Kamil
da Cunha, Elaine F. F.
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Mancini, Daiana T.
Ramalho, Teodorico C.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2015, 33 (09): : 2048 - 2058
[13] In vitro potency of H oximes (HI-6, HLo-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase
Kuca, Kamil
Cabal, Jiri
Kassa, Jiri
Jun, Daniel
Hrabinova, Martina
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2006, 69 (15): : 1431 - 1440

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