Sequence organisation of the class II region of the human MHC

被引：56
|
作者：
Beck, S
Trowsdale, J
机构：
[1] Sanger Ctr, Cambridge CB10 1SA, England
[2] Univ Cambridge, Dept Pathol, Div Immunol, Cambridge CB2 1QP, England
来源：
IMMUNOLOGICAL REVIEWS | 1999年 / 167卷
基金：
英国惠康基金;
关键词：
D O I：
10.1111/j.1600-065X.1999.tb01393.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We present the genomic organisation of the extended class II region of the human MHC. This initial sequence, which is nearing completion, spans about 1.2 Mbp and is at present a composite of more than one haplotype. The sequencing of single haplotypes is planned for the future. The current sequence encompasses all of the known class II genes at the DP, DO, DM, DQ and DR loci as well as the transporter associated with antigen processing (TAP)/low molecular weight protein (LMP) antigen processing genes and the Tapasin locus, at the extended centromeric end.
引用
收藏
页码：201 / 210
页数：10
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