Determination of absolute configuration using heavy atom based co-crystallization method: Halogen atom effects

被引：4
|
作者：
Wang, Jian-Rong [1 ]
Fan, Xiaowu [1 ,2 ]
Ding, Qiaoce [1 ]
Mei, Xuefeng [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China
[2] Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Jiangsu, Peoples R China
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2016年 / 1119卷
基金：
中国国家自然科学基金;
关键词：
Absolute configuration; Co-crystallization; Heavy atom; Cholestanol; L-Ascorbic acid; Single-crystal X-ray diffraction; CO-CRYSTAL;
D O I：
10.1016/j.molstruc.2016.04.084
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Heavy atom (chloride, bromide, and iodide) based co-crystals for determination of absolute configuration (AC) for chiral molecules were synthesized and evaluated. Co-crystals of cholestanol and L-ascorbic acid were analysed and the effects and potential benefits of varying the heavy atom are discussed. Changing the halogen atoms (chloride, bromide, or iodide) affects the co-crystal formation, X-ray absorption, and anomalous dispersion, and hence the ability to determine AC. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：269 / 275
页数：7
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