Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A2 in activated cells

被引：182
|
作者：
Balsinde, J [1 ]
Balboa, MA [1 ]
机构：
[1] Univ Valladolid, Sch Med, Inst Mol Biol & Genet, Eicosanoid Res Div, E-47005 Valladolid, Spain
来源：
CELLULAR SIGNALLING | 2005年 / 17卷 / 09期
关键词：
phospholipase A(2); arachidonic acids; eicosanoids; membrane phospholipid; Ca2+-independent; lysophospholipid; signal transduction;
D O I：
10.1016/j.cellsig.2005.03.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mammalian cells contain several calcium-independent phospholipase A(2) (PLA(2)) enzymes. The best studied of them is the so-called Group VIA PLA(2) (iPLA(2)-VIA), which is an 85-88 kDa enzyme with unique structural features among the PLA(2) superfamily of enzymes, and has been found to play a key role in homeostatic membrane phospholipid metabolism in various cell types. Growing evidence suggests that, in addition to its homeostatic function, iPLA(2)-VIA may also play distinct roles in cellular signaling. This review focuses on the biochemical mechanisms that regulate the activity of iPLA(2)-VIA in activated cells, and the biological functions proposed for this enzyme during stimulus-response coupling. (c) 2005 Elsevier Inc. All rights reserved.
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页码：1052 / 1062
页数：11
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