Paraoxonase L55M polymorphism and coronary artery disease in farmers - A preliminary report

被引：0

作者：

Koochmeshgi, J ^{[1
]}

Hosseini-Mazinani, SM ^{[1
]}

Hoseinpur, N ^{[1
]}

Zare-Karizi, S ^{[1
]}

Hashemi, MJ ^{[1
]}

Azarnik, H ^{[1
]}

Soheilifar, F ^{[1
]}

机构：

[1] Natl Res Ctr Genet Engn & Biotechnol, Tehran, Iran

来源：

FRONTIERS IN CORONARY ARTERY DISEASE | 2003年

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D O I：

暂无

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Paraoxonase gene (PON1) codes for an HDL-bound enzyme with a putative role in protecting LDL against peroxidation. In our ongoing case-control study, we have observed an association between CAD and PONI L55M polymorphism in Iranian population. Interestingly, when CAD cases are divided into two non-farmer and farmer subgroups, this association is strikingly accentuated in the subgroup of farmer CAD patients, becoming extremely significant. While in the non-farmer subgroup of CAD patients it dwindles appreciably. Statistical analysis reveals a significant difference in the frequency of L and M alleles between farmer and non-farmer CAD patients. PON1 is known to catalyze the hydrolysis of xenobiotic pesticides, notably organophosphates. On this basis, a possible gene-environment interaction. is suggested.

引用

页码：17 / 20

页数：4

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