Study of irradiation effects on cytokine secretion from retrovirally-transduced tumor cells: A model for tumor vaccination

被引：0

作者：

Matsubara, H

Tagawa, M

Gunji, Y

Takenaga, K

Sugaya, M

Urashima, T

Koide, Y

Suzuki, T

Asano, T

Ochiai, T

Isono, K

Kageyama, H

Nakamura, Y

Sakiyama, S

机构：

[1] CHIBA UNIV, SCH MED, DEPT BIOCHEM, CHIBA 260, JAPAN

[2] CHIBA CANC RES INST, DIV CHEMOTHERAPY, CHUO KU, CHIBA 260, JAPAN

[3] CHIBA CANC RES INST, DIV BIOCHEM, CHUO KU, CHIBA 260, JAPAN

来源：

ANTICANCER RESEARCH | 1996年 / 16卷 / 02期

关键词：

irradiation; cytokine; retrovirus; tumor vaccine;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have examined the effects of irradiation on the cytokine secretion from genetically modified human esophageal and gastric carcinomas. Both cell lines were transduced retrovirally to secrete interleukin-2, interleukin-6 and granulocyte-macrophage colony-stimulating factor, respectively. The metabolism of all the transduced cells was partially, inhibited by 6 Gy, and greatly inhibited by 20 Gy irradiation. Cytokine productions, however; was not affected by 6 Gy, in many cases, and continued to be detected even after 60 Gy irradiation. The analysis of the dose and time of irradiation in each cytokine producer is useful for the designing of tl!mol vaccine using cytokine gene transfer.

引用

页码：645 / 650

页数：6

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