Study of irradiation effects on cytokine secretion from retrovirally-transduced tumor cells: A model for tumor vaccination

被引：0

作者：

Matsubara, H

Tagawa, M

Gunji, Y

Takenaga, K

Sugaya, M

Urashima, T

Koide, Y

Suzuki, T

Asano, T

Ochiai, T

Isono, K

Kageyama, H

Nakamura, Y

Sakiyama, S

机构：

[1] CHIBA UNIV, SCH MED, DEPT BIOCHEM, CHIBA 260, JAPAN

[2] CHIBA CANC RES INST, DIV CHEMOTHERAPY, CHUO KU, CHIBA 260, JAPAN

[3] CHIBA CANC RES INST, DIV BIOCHEM, CHUO KU, CHIBA 260, JAPAN

来源：

ANTICANCER RESEARCH | 1996年 / 16卷 / 02期

关键词：

irradiation; cytokine; retrovirus; tumor vaccine;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have examined the effects of irradiation on the cytokine secretion from genetically modified human esophageal and gastric carcinomas. Both cell lines were transduced retrovirally to secrete interleukin-2, interleukin-6 and granulocyte-macrophage colony-stimulating factor, respectively. The metabolism of all the transduced cells was partially, inhibited by 6 Gy, and greatly inhibited by 20 Gy irradiation. Cytokine productions, however; was not affected by 6 Gy, in many cases, and continued to be detected even after 60 Gy irradiation. The analysis of the dose and time of irradiation in each cytokine producer is useful for the designing of tl!mol vaccine using cytokine gene transfer.

引用

页码：645 / 650

页数：6

共 50 条

[1] Dendritic cells transduced with an adenoviral vector encoding a model tumor-associated antigen for tumor vaccination
Wan, YH
Bramson, J
Carter, R
Graham, F
Gauldie, J
HUMAN GENE THERAPY, 1997, 8 (11) : 1355 - 1363
[2] Recognition of Tumor Antigens by In Vitro Developed T Cells from Hematopoietic Stem Cells Retrovirally Transduced with TCR Genes
Zhao, Yangbing
Zheng, Zhili
Cohen, Cyrille J.
Rosenberg, Steven A.
Morgan, Richard A.
MOLECULAR THERAPY, 2006, 13 : S175 - S175
[3] Vaccination with retrovirally-transduced dendritic cells introduces cellular and humoral immune responses along with specific protection against prostate antigen-expressing tumors
Liang, SB
Hou, JWS
Peace, DJ
Fowler, DH
Medin, JA
CANCER GENE THERAPY, 2003, 10 : S34 - S35
[4] Development of a novel vaccination therapy against malignant gliomas utilizing cytokine gene-transduced tumor cells
Hirakawa, K
Wakimoto, H
Aoyagi, M
Hamada, H
11TH INTERNATIONAL CONGRESS OF NEUROLOGICAL SURGERY, VOLS 1 AND 2, 1997, : 1717 - 1721
[5] MHC class I and class II presentation of tumor antigen in retrovirally and adenovirally transduced dendritic cells
J Mark Sloan
Michael H Kershaw
Christopher E Touloukian
Rejean Lapointe
Paul F Robbins
Nicholas P Restifo
Patrick Hwu
Cancer Gene Therapy, 2002, 9 : 946 - 950
[6] MHC class I and class II presentation of tumor antigen in retrovirally and adenovirally transduced dendritic cells
Sloan, JM
Kershaw, MH
Touloukian, CE
Lapointe, R
Robbins, PF
Restifo, NP
Hwu, P
CANCER GENE THERAPY, 2002, 9 (11) : 946 - 950
[7] MHC class I and class II presentation of tumor antigen in retrovirally and adenovirally transduced dendritic cells
Sloan, JM
Kershaw, M
Lapointe, R
Robbins, P
Restifo, N
Hwu, P
FASEB JOURNAL, 2001, 15 (05): : A1202 - A1202
[8] Impaired in vivo tumor growth of human pancreatic carcinoma cells retrovirally transduced with GM-CSF gene
Kimura, M
Tagawa, M
Yoshida, Y
Takenouchi, T
Takenaga, K
Azuma, K
Yamaguchi, T
Saisho, H
Sakiyama, S
ANTICANCER RESEARCH, 1998, 18 (1A) : 165 - 170
[9] Effective cytokine gene therapy against an intracranial glioma using a retrovirally transduced IL-4 plus HSVtk tumor vaccine
Okada, H
Giezeman-Smits, KM
Tahara, H
Attanucci, J
Fellows, WK
Lotze, MT
Chambers, WH
Bozik, ME
GENE THERAPY, 1999, 6 (02) : 219 - 226
[10] Effective cytokine gene therapy against an intracranial glioma using a retrovirally transduced IL-4 plus HSVtk tumor vaccine
H Okada
K M Giezeman-Smits
H Tahara
J Attanucci
W K Fellows
M T Lotze
W H Chambers
M E Bozik
Gene Therapy, 1999, 6 : 219 - 226

← 1 2 3 4 5 →