Are mast cells MASTers in HIV-1 infection?

被引：17
|
作者：
Marone, G [1 ]
de Paulis, A [1 ]
Florio, G [1 ]
Petraroli, A [1 ]
Rossi, FW [1 ]
Triggiani, M [1 ]
机构：
[1] Univ Naples Federico II, Div Clin Immunol & Allergy, I-80131 Naples, Italy
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2001年 / 125卷 / 02期
关键词：
AIDS; basophils; CCR3; chemokine; HIV-1; IL-4; IL-13; mast cells; Tat;
D O I：
10.1159/000053802
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
HIV-1 gp120 interacts with IgE V(H)3(+) on the surface of human basophils and mast cells (Fc epsilon RI+ cells), acting as a viral immunoglobulin superantigen, gp120 from different clades induces mediator release from Fc epsilon RI+ cells. gp120 also induces IL-4 and IL-13 synthesis in human basophils. The chemokine receptors CCR3 and CXCR4, which are coreceptors of HIV-1 infection, are expressed by human Fc epsilon RI+ cells. HIV-1 Tat protein is a potent chemoattractant for basophils and lung mast cells, interacting with CCR3. Incubation of basophils with Tat protein upregulates the surface expression of the CCR3 receptor. There is evidence that human Fc epsilon RI+ cells could be infected in vitro by M-tropic HIV-1 strains. Copyright (C) 2001 S. Karger AG, Basel.
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收藏
页码：89 / 95
页数：7
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