Identifying a Ferroptosis-Related Gene Signature for Predicting Biochemical Recurrence of Prostate Cancer

被引:26
|
作者
Lv, Zhengtong [1 ,2 ]
Wang, Jianlong [1 ]
Wang, Xuan [1 ]
Mo, Miao [3 ]
Tang, Guyu [3 ]
Xu, Haozhe [3 ]
Wang, Jianye [1 ,2 ]
Li, Yuan [4 ]
Liu, Ming [1 ,2 ]
机构
[1] Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Natl Ctr Gerontol,Dept Urol, Beijing, Peoples R China
[2] Peking Union Med Coll & Chinese Acad Med Sci, Grad Sch, Beijing, Peoples R China
[3] Cent South Univ, Xiangya Hosp, Dept Urol, Changsha, Peoples R China
[4] Cent South Univ, Xiangya Hosp 2, Dept Urol, Changsha, Peoples R China
来源
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷
基金
中国国家自然科学基金;
关键词
prostate cancer; TCGA; MSKCC; ferroptosis; prognosis; biochemical recurrence; NATURAL-HISTORY; OVEREXPRESSION; AKR1C1; PROGRESSION; SYNTHASE; SLC1A5; FANCD2; TUMORS; CELLS; ACSL4;
D O I
10.3389/fcell.2021.666025
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Ferroptosis induced by lipid peroxidation is closely related to cancer biology. Prostate cancer (PCa) is not only a malignant tumor but also a lipid metabolic disease. Previous studies have identified ferroptosis as an important pathophysiological pathway in PCa development and treatment, but its role in the prognosis of PCa is less well known. In this study, we constructed a nine-ferroptosis-related gene risk model that demonstrated strong prognostic and therapeutic predictive power. The higher risk score calculated by the model was significantly associated with a higher ferroptosis potential index, higher Ki67 expression, higher immune infiltration, higher probability of biochemical recurrence, worse clinicopathological characteristics, and worse response to chemotherapy and antiandrogen therapy in PCa. The mechanisms identified by the gene set enrichment analysis suggested that this signature can accurately distinguish high- and low-risk populations, which is possibly closely related to variations in steroid hormone secretion, regulation of endocrine processes, positive regulation of humoral immune response, and androgen response. Results of this study were confirmed in two independent PCa cohorts, namely, The Cancer Genome Atlas cohort and the MSK-IMPACT Clinical Sequencing Cohort, which contributed to the body of scientific evidence for the prediction of biochemical recurrence in patients with PCa. In addition, as the main components of this signature, the effects of the AIFM2 and NFS1 genes on ferroptosis were evaluated and verified by in vivo and in vitro experiments, respectively. The above findings provided new insights and presented potential clinical applications of ferroptosis in PCa.
引用
收藏
页数:19
相关论文
共 50 条
  • [21] Development and Validation of a Novel Ferroptosis-Related Gene Signature for Predicting Prognosis and the Immune Microenvironment in Gastric Cancer
    Wang, Feng
    Chen, Cheng
    Chen, Wei-Peng
    Li, Zu-Ling
    Cheng, Hui
    BIOMED RESEARCH INTERNATIONAL, 2021, 2021
  • [22] Identification of ferroptosis-related signature predicting prognosis and therapeutic responses in pancreatic cancer
    Chung, Ting Ting
    Piao, Zanyue
    Lee, Seung Jin
    SCIENTIFIC REPORTS, 2025, 15 (01):
  • [23] A Novel Ferroptosis-Related Gene Signature Predicts Recurrence in Patients With Pancreatic Ductal Adenocarcinoma
    Feng, Zengyu
    Chen, Peng
    Li, Kexian
    Lou, Jianyao
    Wu, Yulian
    Li, Tao
    Peng, Chenghong
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2021, 8
  • [24] Identification and Validation of a Prognostic Signature for Prostate Cancer Based on Ferroptosis-Related Genes
    Liu, Huan
    Gao, Lei
    Xie, Tiancheng
    Li, Jie
    Zhai, Ting-shuai
    Xu, Yunfei
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [25] Identification and validation of a ferroptosis-related gene signature for predicting survival in skin cutaneous melanoma
    Ping, Shuai
    Wang, Siyuan
    Zhao, Yingsong
    He, Jinbing
    Li, Guanglei
    Li, Dinglin
    Wei, Zhuo
    Chen, Jianghai
    CANCER MEDICINE, 2022, 11 (18): : 3529 - 3541
  • [26] Construction of a Novel Ferroptosis-Related Gene Signature for Predicting Survival of Patients With Lung Adenocarcinoma
    Song, Xiaojie
    Wu, Liqun
    Wang, Guangqiang
    Liu, Baoyi
    Zhu, Wenyong
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [27] Construction of a Ferroptosis-Related Gene Signature for Predicting Survival and Immune Microenvironment in Melanoma Patients
    Zeng, Ni
    Ma, Liwen
    Cheng, Yuxin
    Xia, Qingyue
    Li, Yueyue
    Chen, Yihe
    Lu, Zhiyu
    Lu, Qian
    Jiang, Feng
    Luo, Dan
    INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 2021, 14 : 6423 - 6438
  • [28] Exploration and validation of a novel ferroptosis-related gene signature predicting the prognosis of intrahepatic cholangiocarcinoma
    Yao, Xinfei
    Chen, Bo
    Wang, Mingxun
    Zhang, Sina
    He, Bangjie
    Shi, Zhehao
    Deng, Tuo
    Bao, Wenming
    Wang, Yi
    Chen, Gang
    Bo, Zhiyuan
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2022, 54 (09) : 1376 - 1385
  • [29] Identification of a ferroptosis-related gene signature (FRGS) for predicting clinical outcome in lung adenocarcinoma
    Wang, Sheng
    Wu, Chunlei
    Ma, Dehua
    Hu, Quanteng
    PEERJ, 2021, 9
  • [30] Identification of the ferroptosis-related prognostic gene signature in mesothelioma
    Wang, Zairui
    Huang, Jialin
    Yang, Min
    Fu, Liren
    Liu, Shijie
    Huang, Jianghua
    Han, Jingjing
    Zhao, Xiaohui
    GENE, 2024, 919