t-PA activity and antigen in thrombolytic treatment with rt-PA in children

被引：0
|
作者：
RisseeuwAppel, IM
Dekker, I
Stigter, RL
vanKesselBakvis, CL
机构：
来源：
FIBRINOLYSIS | 1996年 / 10卷
关键词：
D O I：
10.1016/S0268-9499(96)80050-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effect of increasing doses of rt-PA (Alteplase) in catheter related thrombi in children was studied. The data suggest that optimal local fibrinolytic treatment is realized at a systemic level of 0.80 ng/ml of t-PA, which was reached with a dosis of 0.10 mg/kg hour directly infused via the affected catheter. After the introduction of rt-PA the level of PAI-1 activity immediately fell below 2 IU/ml, whereas the amount of PAI-1 antigen stayed at the same level throughout rt-PA treatment.
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页码：57 / 58
页数：2
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