Experimental model of pyridoxine (B6) deficiency-induced neuropathy

被引:15
|
作者
Dellon, AL
Dellon, ES
Tassler, PL
Ellefson, RD
Hendrickson, M
机构
[1] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA
[2] Johns Hopkins Univ, Sch Med, Div Plast Surg & Neurosurg, Baltimore, MD USA
[3] Dept Hyg & Publ Hlth, Burlington, VT USA
[4] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
[5] Cleveland Clin, Cleveland, OH 44106 USA
关键词
D O I
10.1097/00000637-200108000-00008
中图分类号
R61 [外科手术学];
学科分类号
摘要
A pyridoxine (B-6) dietary deficiency was studied in female adult Sprague-Dawley rats by hind-limb walking-track analysis. Serum levels of pyridoxine and three metabolites were quantified by high-pressure liquid chromatography with fluorescence measurement. Morphometric analysis of the sciatic and posterior tibia[ nerves (from within the tarsal tunnel) was performed after I year on a diet deficient in vitamin B-6. The B-6-deficient rats developed abnormal walking-track patterns by 8 months, and these track parameters were different from age- and sex-matched normal diet control rats at the p < 0.05 level. Adding B-6 at 10 parts per million to the diet then partially corrected these parameters, whereas the addition of 30 parts per million B-6 corrected the abnormal pattern completely. Serum pyridoxal concentration correlated with the functional parameters, dropping from a mean of 115 mg per liter to 39.5 mg per liter (p < 0.05), and correcting with the B-6 additive. Morphometric analysis demonstrated that the B-6-deficient nerve from the tarsal tunnel had a decreased nerve fiber density (p < 0.001), with a normal total myelinated nerve fiber number, and an increased axon-to-myelin ratio (p < 0.003). It is concluded that a diet totally deficient in vitamin B-6 results in a peripheral neuropathy.
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收藏
页码:153 / 160
页数:8
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