Circular RNA in Aging and Age-Related Diseases

被引：27
|
作者：
Yang, Deying [1 ]
Yang, Katie [2 ]
Yang, Mingyao [1 ]
机构：
[1] Sichuan Agr Univ, Inst Anim Genet & Breeding, Chengdu, Sichuan, Peoples R China
[2] Cambridge Univ Hosp, Addenbrookes Hosp, Cambridge Biomed Campus, Cambridge, England
来源：
AGING AND AGING-RELATED DISEASES: MECHANISMS AND INTERVENTIONS | 2018年 / 1086卷
关键词：
Circular RNA; Aging; Age-related diseases; Molecular function; Biomarker; COLORECTAL-CANCER; CELL-GROWTH; EXPRESSION; REVEALS; IDENTIFICATION; SENESCENCE; BIOMARKER; GENE; MIGRATION; INVASION;
D O I：
10.1007/978-981-13-1117-8_2
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Circular RNAs (circRNAs) are widely present and participate in a variety of biological regulatory activities as a novel type of endogenous noncoding RNA molecule. With advances in RNA structure and function analysis, it was found that circRNAs are present in a myriad of life processes and longevity in model organisms such as mice, flies, and worms. Accumulating evidence indicates the involvement of circRNAs in regulation of age-related pathologies such as cancer, diabetes, cardiovascular disorders, and neurodegenerative disease, suggesting that circRNAs may have great potential implications in clinical and research fields. In this chapter, we review recent advances in circRNA functions and mechanisms and discuss their roles in aging and age-related diseases. It will provide insight into the regulatory roles of circRNAs in aging and age-related diseases.
引用
收藏
页码：17 / 35
页数：19
相关论文
共 50 条
  • [41] Long noncoding RNAs in aging and age-related diseases
    Kour, Sukhleen
    Rath, Pramod C.
    AGEING RESEARCH REVIEWS, 2016, 26 : 1 - 21
  • [42] DNA Methylation Biomarkers in Aging and Age-Related Diseases
    Salameh, Yasmeen
    Bejaoui, Yosra
    El Hajj, Nady
    FRONTIERS IN GENETICS, 2020, 11
  • [43] AGE-RELATED DISEASES AND NORMAL AGING - THE NATURE OF THE RELATIONSHIP
    FORBES, WF
    THOMPSON, ME
    JOURNAL OF CLINICAL EPIDEMIOLOGY, 1990, 43 (02) : 191 - 193
  • [44] Molecular inflammation: Underpinnings of aging and age-related diseases
    Chung, Hae Young
    Cesari, Matteo
    Anton, Stephen
    Marzetti, Emanuele
    Giovannini, Silvia
    Seo, Arnold Young
    Carter, Christy
    Yu, Byung Pal
    Leeuwenburgh, Christiaan
    AGEING RESEARCH REVIEWS, 2009, 8 (01) : 18 - 30
  • [45] Sirtuins and their Biological Relevance in Aging and Age-Related Diseases
    Zhao, Lijun
    Cao, Jianzhong
    Hu, Kexin
    He, Xiaodong
    Yun, Dou
    Tong, Tanjun
    Han, Limin
    AGING AND DISEASE, 2020, 11 (04): : 927 - 945
  • [46] The application of aptamers in the field of aging and age-related diseases
    Xu, LiuJun
    Jiang, Beier
    Qiu, WenJing
    Jiang, Chunxia
    Zhang, Feng
    Tan, Weihong
    CLINICAL AND TRANSLATIONAL DISCOVERY, 2024, 4 (04):
  • [47] Prevalence of age-related eye diseases in aging primates
    Lu, Qingjun
    Teng, Yufei
    Peng, Xiaoyan
    Liu, Xiyao
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (13)
  • [48] Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases
    Zhou, Dan-Dan
    Luo, Min
    Huang, Si-Yu
    Saimaiti, Adila
    Shang, Ao
    Gan, Ren-You
    Li, Hua-Bin
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2021, 2021
  • [49] Multimodal Omics Approaches to Aging and Age-Related Diseases
    Ji, Qianzhao
    Jiang, Xiaoyu
    Wang, Minxian
    Xin, Zijuan
    Zhang, Weiqi
    Qu, Jing
    Liu, Guang-Hui
    PHENOMICS, 2024, 4 (01): : 56 - 71
  • [50] MicroRNAs as Peripheral Biomarkers in Aging and Age-Related Diseases
    Kumar, S.
    Vijayan, M.
    Bhatti, J. S.
    Reddy, P. H.
    MOLECULAR BIOLOGY OF AGING, 2017, 146 : 47 - 94
12345