TLC Bioautography-guided Isolation and Antimicrobial, Antifungal Effects of 12 Alkaloids from Hylomecon japonica Roots

被引：0

作者：

Xue, Xuanji ^{[1
]}

Zhang, Hui ^{[1
]}

Zhang, Xinxin ^{[1
]}

Liu, Xia ^{[1
]}

Xi, Ke ^{[1
]}

Han, Yanxia ^{[1
]}

Guo, Zengjun ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Sch Pharm, 76 West Yanta Rd, Xian 710061, Peoples R China

来源：

NATURAL PRODUCT COMMUNICATIONS | 2017年 / 12卷 / 09期

关键词：

TLC bioautography-guided isolation; Antimicrobial and Antifungal effect; Hylomecon japonica; Alkaloids; ANTIBACTERIAL ACTIVITIES; CHEMICAL-COMPOSITION; ANTIOXIDANT; IDENTIFICATION;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Hylomecon japonica (Thunb.) Prantl. is a Chinese medicinal plant whose active components and their antimicrobial mechanism was studied by TLC bioautography-guided isolation and identification of 12 alkaloids and their antimicrobial activities evaluated using the standard broth microdilution method. The benzophenanthridine isoquinoline alkaloids showed the strongest inhibitory activity against Gram-positive bacteria. Analysis of conductivity changes and observation of TEM images revealed that the antimicrobial mechanism involved cell integrity damage and cell division arrest.

引用

页码：1439 / 1442

页数：4

共 26 条

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